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TranscriptomicsEpiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages
Embryonic stem cells (ESCs) comprise at least two populations of cells with divergent states of pluripotency. Here, we show that epiblast stem cells (EpiSCs) also comprise two distinct cell populations that can be distinguished by the expression of a specific Oct4-GFP marker. These two subpopulation...
ORGANISM(S): Mus musculus 
2011-02-24 | E-GEOD-17984 | biostudies-arrayexpress
TranscriptomicsHuman adult germline stem cells in question
Conrad et al. Nature 456, 344–349 (2008) have generated human adult germline stem cells (haGSCs) from human testicular tissue, which they claim have similar pluripotent properties to human embryonic stem cells (hESCs). Here we investigate the pluripotency of haGSCs by using global gene-expression ...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-17772 | biostudies-arrayexpress
TranscriptomicsSox2 Levels Define Pluripotent Ground States and Reprogramming Potential
Pluripotent stem cell lines derived from embryos of different stages have distinct pluripotent ground states, but similar levels of the transcription factor Oct4. Epiblast-derived pluripotent stem cells (EpiSCs), in contrast to embryonic stem (ES) cells, cannot form chimeras. We show that EpiSCs exp...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-15358 | biostudies-arrayexpress
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