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MetabolomicsProlonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
Emerging new evidence highlights the importance of prolonged daily fasting periods for the health and survival benefits of calorie restriction (CR) and time-restricted feeding (TRF) in male mice; however, little is known about the impact of these feeding regimens in females. We placed 14-month-old f...
2024-05-14 | MTBLS790 | MetaboLights
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsAntitumor Activity of (R,R’)-4-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouse
(R,R’)-4-methoxy-1-naphthylfenoterol (MNF) inhibits in vitro proliferation of several types of cancer cell lines. In this study, the in vivo antitumor effects of MNF were evaluated using rat C6 glioma cells implanted subcutaneously into the lower flank of 5 week-old NMRI/Nude female Swiss mice. Thre...
ORGANISM(S): Rattus norvegicus 
2015-08-06 | E-GEOD-45307 | biostudies-arrayexpress
TranscriptomicsDNA microarray analysis of the anti-inflammatory effects of PDTC on IL-6 signaling in HepG2 cells
Interleukin-6 (IL-6) is a proinflammatory cytokine that exerts a wide range of cellular, physiological and pathophysiological responses. Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6 through impairment in STAT3 activation and downstream signaling. Here, a transcr...
ORGANISM(S): Homo sapiens 
2012-01-05 | E-GEOD-14632 | biostudies-arrayexpress
ProteomicsAcetylation changes in NQO1 overexpression in Mouse Skeletal Mucscle
In this manuscript we have explored the role of both Nrf2 and NQO1 in protection against diet-induced metabolic syndrome and demonstrate that both Nrf2 and NQO1 provide protection against HFD-induced adverse phenotypes in a mouse model
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015070 | Pride
Nqo1 Mouse Metabolic syndrome Quantitation Acetylomics Skeletal muscle 
TranscriptomicsCaloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo
Caloric restriction (CR) without malnutrition is one of the most consistent strategies for increasing mean and maximal lifespan and delaying the onset of age-associated diseases. Stress resistance is a common trait of many long-lived mutants and life-extending interventions, including CR. Indeed, be...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-67430 | biostudies-arrayexpress
TranscriptomicsSW480R
SW480R is an APC mut, KRAS mut, P53 mut CRC cell line. PROX1 transcription factor, target of Wnt pathway in CRC, is our protein of interest.SW480R cells are PROX1 positive. We suppressed through siRNA transfection the expression of PROX1 protein or non-targeting siRNA, using two different siRNA. Aft...
ORGANISM(S): Homo Sapiens 
2014-09-18 | E-MTAB-2021 | biostudies-arrayexpress
TranscriptomicsDLD1
DLD1 is an APC mut, KRAS mut, P53 mut CRC cell line. PROX1 transcription factor, target of Wnt pathway in CRC, is our protein of interest.DLD1 cells are PROX1 negative. We overexpressed through lentiviral expression PROX1 protein or the empty vector psd44, through selection of the cells in puromycin...
ORGANISM(S): Homo Sapiens 
2014-09-18 | E-MTAB-2020 | biostudies-arrayexpress
UnknownOccupational cataracts and lens opacities in interventional cardiology (O'CLOC study): are X-Rays involved? Radiation-induced cataracts and lens opacities.
Not available
S-EPMC2944370 | biostudies-literature
TranscriptomicsThe SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet
The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD+ deacetylase, improves metabolism and confers protection against physiological and cognitive distur...
ORGANISM(S): Mus musculus 
2014-12-20 | E-GEOD-50987 | biostudies-arrayexpress
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