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TranscriptomicsRole of retinoblastoma protein (Rb) in mouse Sertoli cells function
Gene expression profiling study of Sertoli cells (Sc)-specific Retinoblastoma (Rb) knockout (KO) mice. We generated a Sc-specific Rb knockout (Sc-RbKO) line and characterised its testicular phenotype. Sc-RbKO showed a progressive germ cell depletion leading to infertility and Sc dysfunction. We obse...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-22234 | biostudies-arrayexpress
TranscriptomicsNFIB is a driver of SCLC initiation, progression and metastasis in mouse and marks metastatic disease in patients
Small Cell Lung Cancer (SCLC) is the most aggressive type of lung cancer with early metastatic dissemination and invariable development of resistant disease for which no effective treatment is available to date. Mouse models of SCLC based on inactivation of Rb1 and Trp53 developed earlier showed fre...
ORGANISM(S): Mus musculus 
2016-07-29 | E-GEOD-82005 | biostudies-arrayexpress
TranscriptomicsChromatin position effects assayed by thousands of reporters integrated in parallel (cell lines with mPGK IRs)
Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of low throughput. Here we describe a multiplexing approach for the parallel monitoring of transcripti...
ORGANISM(S): Mus musculus 
2013-08-16 | E-GEOD-49807 | biostudies-arrayexpress
TranscriptomicsChromatin position effects assayed by thousands of reporters integrated in parallel (mPGK TRIP pools)
Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of low throughput. Here we describe a multiplexing approach for the parallel monitoring of transcripti...
ORGANISM(S): Mus musculus 
2013-08-16 | E-GEOD-48608 | biostudies-arrayexpress
TranscriptomicsChromatin position effects assayed by thousands of reporters integrated in parallel (tet-Off TRIP pools)
Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of low throughput. Here we describe a multiplexing approach for the parallel monitoring of transcripti...
ORGANISM(S): Mus musculus 
2013-08-16 | E-GEOD-49806 | biostudies-arrayexpress
TranscriptomicsChromatin position effects assayed by thousands of reporters integrated in parallel (RNA-Seq)
Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of low throughput. Here we describe a multiplexing approach for the parallel monitoring of transcripti...
ORGANISM(S): Mus musculus 
2013-08-16 | E-GEOD-48607 | biostudies-arrayexpress
UnknownAcute Cardiac Care 2012
Not available
S-EPMC3760571 | biostudies-literature
UnknownEfficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
Not available
S-EPMC5731244 | biostudies-literature
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