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UnknownPhase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas.
Not available
S-EPMC3867644 | biostudies-literature
ProteomicsChromatin accessibility promotes hematopoietic and leukemia stem cell activity
Chromatin organization is a highly orchestrated process that influences gene expression, in part by modulating access of regulatory factors to DNA and nucleosomes. We found that the chromatin accessibility regulator HMGN1, a target of recurrent DNA copy gains in leukemia, controls myeloid differenti...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-25 | PXD017054 | Pride
Hmgn1 Chromatin Leukemia Aml 
TranscriptomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [RNA-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. RNA-Seq in primary adult human erythroid cells treated with UNC0638 or the vehicle control (DMSO) in biological triplicates.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-71421 | biostudies-arrayexpress
GenomicsEHMT1 and EHMT2 inhibition induce fetal hemoglobin expression [ChIP-seq]
Using UNC0638 and genetic assays to inhibit EHMT1/2 and derepress fetal hemoglobin in adult hematopoietic cells. ChIP-seq for 2 histone modifications and total H3 (for quantitative normalization) in biological triplicates of cord blood, adult bone marrow, and UNC0638-treated adult bone marrow.
ORGANISM(S): Homo sapiens 
2015-11-02 | E-GEOD-69516 | biostudies-arrayexpress
UnknownMethotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients With Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial.
Not available
S-EPMC4486345 | biostudies-literature
TranscriptomicsA long noncoding RNA protects the heart from pathological hypertrophy
The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo antisense transcription1, including myosin heavy chain 7 (Myh7), which encodes molecular motor proteins for heart contraction2. Her...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-49716 | biostudies-arrayexpress
UnknownArrhythmic risk prediction in arrhythmogenic right ventricular cardiomyopathy: external validation of the arrhythmogenic right ventricular cardiomyopathy risk calculator.
Not available
S-EPMC9392650 | biostudies-literature
UnknownPerformance evaluation of automated white matter hyperintensity segmentation algorithms in a multicenter cohort on cognitive impairment and dementia.
Not available
S-EPMC9877422 | biostudies-literature
UnknownSex-specific modulation of amyloid-β on tau phosphorylation underlies faster tangle accumulation in females.
Not available
S-EPMC10994548 | biostudies-literature
UnknownOutcome after reduced chemotherapy for intermediate-risk neuroblastoma.
Not available
S-EPMC2993160 | biostudies-literature
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