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TranscriptomicsExpression data from wild-type and HMGN1 knockout mice injected with N-nitrosodiethylamine
HMGN1 contributes to the shortened latency of liver tumorigenesis by changing a chromatin structure and expression of relevant genes To assess the molecular mechanisms underlying accelerated tumor development in Hmgn1-/- mice, we performed the gene expression profiling of liver cells at early stages...
ORGANISM(S): Mus musculus 
2013-08-24 | E-GEOD-44356 | biostudies-arrayexpress
GenomicsGenomic Profiling of HMGN1 Reveals an Association with Chromatin at Regulatory Regions
High mobility group (HMG) proteins interact with other architectural proteins to regulate chromatin structure. We performed genome-wide mapping experiments to examine the distribution of HMGN1 across the human genome. We discovered that HMGN1 proteins are enriched at regulatory regions such as DNas...
ORGANISM(S): Homo sapiens 
2010-11-30 | E-GEOD-25674 | biostudies-arrayexpress
ProteomicsRapid Proteomic Screen of CRISPR Experiment Outcome by Data Independent Acquisition Mass Spectrometry: A Case Study for HMGN1
CRISPR-Cas gene editing holds substantial promise in many biomedical disciplines and basic research. Due to the important functional implications of non-histone chromosomal protein HMG-14 (HMGN1) in regulating chromatin structure and tumor immunity, we performed gene knockout of HMGN1 by CRISPR in c...
ORGANISM(S): Homo sapiens (Human) 
2019-03-26 | PXD011952 | Pride
Crispr Dia Proteomics Hmgn1 
ProteomicsHMGN1 and HMGN2 are recruited to acetylated and histone variant H2A.Z-containing nucleosomes to regulate chromatin state and transcription
The High Mobility Group Nucleosome-binding (HMGN) proteins are small abundant nuclear proteins that directly bind nucleosomes and constitute a major component of chromatin. HMGN proteins specifically localize to enhancers and actively transcribed genes across the genome, however the roles of HMGN pr...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-22 | PXD070369 | Pride
E1a binding protein p300 (p300) Nucleosome Epigenetics Genome structure Gene expression Histone acetylation Chromatin High mobility group proteins 
GenomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [ChIP-seq]
Children with Down syndrome (DS) have a 20-fold increased risk of developing B cell acute lymphoblastic leukemia (B-ALL). Polysomy 21 (i.e., extra copies of chr.21) is also the most frequent somatic aneuploidy among all B-ALLs. Additional B-ALLs harbor intrachromosomal amplifications of chr.21q22 (i...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48534 | biostudies-arrayexpress
UnknownExpression of nucleosomal protein HMGN1 in the cycling mouse hair follicle.
Not available
S-EPMC2738608 | biostudies-literature
TranscriptomicsTriplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation [RNA-Seq]
Down syndrome (DS) confers a 20-fold increased risk of B cell acute lymphoblastic leukemia (ALL), yet the mechanisms underlying this association are undefined.  We show that triplication of only 31 genes orthologous to the putative DS Critical Region (DSCR) on chr.21q22 is sufficient to promote B ce...
ORGANISM(S): Mus musculus 
2014-04-20 | E-GEOD-48553 | biostudies-arrayexpress
UnknownChromosomal protein HMGN1 enhances the acetylation of lysine 14 in histone H3.
Not available
S-EPMC1201349 | biostudies-literature
UnknownFunction of chromatin modifier Hmgn1 during neural crest and craniofacial development.
Not available
S-EPMC8922215 | biostudies-literature
UnknownThe Alarmin HMGN1 contributes to antitumor immunity and is a potent immunoadjuvant.
Not available
S-EPMC6309998 | biostudies-literature
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