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ProteomicsComprehensive analysis of transcripts and proteins relative abundance during Plasmodium falciparum blood stages
We aimed to evaluate the relevance of mRNA study as a proxy of protein expression in sequestered parasites. To do so, we conducted a proteotranscriptomic analysis using five independent P. falciparum laboratory strains samples. RNA sequencing was performed on circulating ring stage parasites and LC-...
ORGANISM(S): Plasmodium falciparum 
2021-02-10 | PXD020052 | Pride
Plasmodium falciparum  rna-seq  fpkm  lc-ms/ms  label free quantification  transcriptomes  proteomes  transcripts and proteins expression correlation 
ProteomicsInfected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria
Cerebral malaria (CM), the most lethal complication of Plasmodium falciparum severe malaria (SM), claims the life of 15 to 25% of admitted children despite treatment. P. falciparum infects and multiplies in human erythrocytes, contributing to anemia, parasite sequestration, and inflammation in the h...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2024-02-01 | PXD043033 | Pride
Severe malaria Plasma Plasmodium falciparum Lc-ms/ms 
ProteomicsInfected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria.
Severe malaria (SM) is a life-threatening condition caused by Plasmodium falciparum and the most severe presentation is cerebral malaria (CM) mostly affecting children under five years old. The comprehensive understanding of the complex mechanisms driving the pathophysiology of CM, which encompasses...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2024-02-01 | PXD042503 | Pride
Infected erythrocytes Severe malaria Plasma Infected erythrocytes severe malaria Plasmodium falciparum Lc-ms/ms 
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