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ProteomicsNucleolin rescues TDP-43 toxicity in yeast and human cell models
TDP-43 is a nuclear protein involved in pivotal processes, extensively studied for its implication in neurodegenerative disorders. TDP-43 cytosolic inclusions are a common neuropathologic hallmark in amyotrophic lateral sclerosis (ALS) and related diseases, and it is now established that TDP-43 misf...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-03-26 | PXD022432 | Pride
Nucleolin Tmt Als Nucleo-cytoplasmic transport Ftd Tdp-43 proteinopathies Lc-hrms/ms Neurodegenerative disorders 
ProteomicsPerturbations of the proteome in primary astrocytes from the hSOD1(G93A) ALS mouse model
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease whose pathophysiology is largely unknown. Despite motor neuron death is recognized as the key event in ALS, astrocytes dysfunctionalities and neuroinflammation were demonstrated to accompany and probably even drive motor ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD026576 | Pride
Spinal cord astrocytes Amyotrophic lateral sclerosis Mouse Lc-hrms/ms 
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