Sort   by:  
 Page size 
ProteomicsHalofuginone, a tRNA-synthetase inhibitor, decreases bulk protein synthesis independently of the integrated stress response
The integrated stress response (ISR), a vital homeostatic pathway, is an emerging therapeutic target for a broad range of clinical indications. Halofuginone (HF) is a phase 2 clinical compound that induces the ISR by inhibiting the glutamyl-prolyl-tRNA synthetase (EPRS). Here we report that although...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-04-27 | PXD028744 | Pride
Trna synthetase Stress responses Integrated stress response Gcn2 Translation 
ProteomicsRecruitment of trimeric eIF2 by phosphatase non-catalytic subunit PPP1R15B
HDX-MS of R15B and it's interactions with trimeric eIF2 substrate. Here we integrated diverse approaches to elucidate how the PP1 non-catalytic subu-nit PPP1R15B (R15B) captures its full trimeric eIF2 substrate. We found that the substrate recruitment module of R15B is largely disordered with three...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD047538 | Pride
Hdx-ms Hd-ms 
UnknownThe VIII International Congress on Stress Proteins in Biology and Medicine: taynna henkea.
Not available
S-EPMC5823810 | biostudies-literature
UnknownCellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response
Not available
S-SCDT-EMBOJ-2021-109985 | biostudies-other
Sort   by:  
 Page size