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GenomicsChromatin and Sequence Features that Define the Fine and Gross Structure of Genomics Methylation Patterns
We report a new method for genome-wide methylation profiling that is able to probe methylation status in both single-copy DNA and interspersed repeats. This method, MethylMAPS, uses methylation-sensitive and -dependent enzymes to fractionate the genome according to methylation state. Methylated an...
ORGANISM(S): Mus musculus 
2010-04-16 | E-GEOD-21242 | biostudies-arrayexpress
TranscriptomicsAbnormal X chromosome inactivation and sex-specific gene dysregulation after ablation of FBXL10
The FBXL10 protein (also known as KDM2B, JHDM1B, CXXC2, and NDY1) is bound to essentially all CpG-rich promoters in the mammalian genome. FBXL10 is expressed as two isoforms: FBXL10-1, a longer form that contains an N-terminal JmjC domain with C- terminal F-box, CXXC, PHD, RING, and leucine rich rep...
ORGANISM(S): Mus musculus 
2016-05-31 | E-GEOD-76552 | biostudies-arrayexpress
TranscriptomicsA piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
We examined the construction of the piRNA system in the restricted developmental window in which methylation patterns are set during mammalian embryogenesis. We find robust expression of two Piwi family proteins, MIWI2 and MILI. Their associated piRNA profiles reveal differences from Drosophila wher...
ORGANISM(S): Mus musculus 
2008-10-01 | E-GEOD-12757 | biostudies-arrayexpress
GenomicsFBXL10 and the Protection of Polycomb-bound Genes from Hypermethylation (RRBS)
Nearly all CpG-dense promoters are occupied by the multi-domain chromosomal protein FBXL10. We show here that complete inactivation of the Fbxl10 gene leads to dense de novo methylation only of the promoters that are co-occupied by both FBXL10 and by Polycomb Repressive Complexes; this results in pe...
ORGANISM(S): Mus musculus 
2015-04-06 | E-GEOD-65580 | biostudies-arrayexpress
TranscriptomicsFBXL10 and the Protection of Polycomb-bound Genes from Hypermethylation (RNA-Seq)
Nearly all CpG-dense promoters are occupied by the multi-domain chromosomal protein FBXL10. We show here that complete inactivation of the Fbxl10 gene leads to dense de novo methylation only of the promoters that are co-occupied by both FBXL10 and by Polycomb Repressive Complexes; this results in pe...
ORGANISM(S): Mus musculus 
2015-04-06 | E-GEOD-65582 | biostudies-arrayexpress
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