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ProteomicsA transphyletic study of metazoan β-catenin protein complexes
β-catenin plays a vital role in various biological processes, such as body axis determination and cell differentiation, during embryonic development in metazoans. These β-catenin functions are thought to be exerted through complexes formed with various types of proteins. Although β-catenin complex p...
ORGANISM(S): Cellular Organisms 
2025-01-21 | PXD053223 | JPOST Repository
ProteomicsHuman platelet β-catenin interaction proteome
In nucleated cells, β-catenin, the key downstream effector of this pathway, is a dual function protein, regulating the coordination of gene transcription and cell–cell adhesion. The specific role of β-catenin in the anucleate platelet however remains elusive. Here, we performed a label-free quanti...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD008130 | Pride
Human Mass spectrometry Label-free quantitation Platelets Β-catenin Co-immunoprecipitation 
TranscriptomicsBeta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt/beta-catenin signaling
To validate the suitability of two commonly used colorectal cancer cell lines, DLD1 and SW480, as model systems to study colorectal carcinogenesis, we treated these cell lines with beta-catenin siRNA and identified beta-catenin target genes using DNA microarrays. The list of identified target genes ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-44097 | biostudies-arrayexpress
TranscriptomicsIdentification of beta-catenin-associated RNAs in myeloid leukaemia cells through RIP-seq
Myeloid cell lines (K562 and HEL) were treated overnight with CHIR99021 or a vehicle control (DMSO). CHIR99021 treatment inhibits GSK3B within the destruction complex functioning in Wnt/beta-catenin signalling pathway, thereby preventing beta-catenin degradation and promoting its stabilization. Foll...
ORGANISM(S): Homo sapiens 
2025-04-08 | E-MTAB-14675 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse pancreas at embryonic days 14.5 and 16.5 from animals lacking beta-catenin, a mediator of Wnt signaling and a component of the cadherin-catenin epithelial adhesion complex
Beta-catenin is an essential mediator of canonical Wnt signaling and a central component of the cadherin-catenin epithelial adhesion complex. Dysregulation of beta-catenin expression has been described in pancreatic neoplasia. Newly published studies have suggested that beta-catenin is critical for ...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-7430 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human multiple myeloma cells ( MM1.S) cells with control or beta-catenin knockdown.
MM1.S cells stably transduced with control or beta-catenin shRNA were established. Total RNA was isolated from 5x 10^6 cells of each in triplicate. Experiment Overall Design: Comparative gene expression profiling in multiple myeloma.
ORGANISM(S): Homo sapiens 
2009-09-15 | E-GEOD-17385 | biostudies-arrayexpress
TranscriptomicsBeta-catenin status in pediatric medulloblastomas
Medulloblastoma is the most frequent malignant pediatric brain tumor. Considerable efforts are dedicated to identify markers that help to refine treatment strategies. The activation of the Wnt/beta-catenin pathway occurs in 10-15% of medulloblastomas and has been recently described as a marker for f...
ORGANISM(S): Homo sapiens 
2009-02-02 | E-GEOD-12992 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse intestinal crypts upon deletion of beta-catenin
The Wnt signaling pathway is deregulated in over 90% of human colorectal cancers. β Catenin, the central signal transducer of the Wnt pathway, can directly modulate gene expression by interacting with transcription factors of the TCF/LEF-family. In the present study we investigate the role of Wnt s...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8818 | biostudies-arrayexpress
MetabolomicsExtracts from sweet sorghum (Sorghum bicolor), a feedstock for biorefining, suppressed proliferation and elevated apoptosis in human colon cancer stem cells via suppression of Wnt/beta-catenin signaling pathway
In colorectal cancer, p53 is commonly inactivated, associated with chemo-resistance, and marks the transition from non-invasive to invasive disease. Cancers, including colorectal cancer, are thought to be diseases of aberrant stem cell populations, as stem cells are able to self-renew, making them l...
2014-05-01 | MTBLS69 | MetaboLights
ProteomicsIdentification of β-Catenin-Interacting Proteins in Nuclei of Aquaporin-2-Expressing Rat Collecting Duct Cells
The gene encoding the aquaporin-2 water channel is regulated transcriptionally in response to vasopressin. In the renal collecting duct, vasopressin stimulates the nuclear translocation and phosphorylation (at Ser552) of β-catenin, a multifunctional protein that can act as a transcriptional co-regul...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD005792 | Pride
Transcription Transcriptional co-regulator Aquaporin-2 Kidney 
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