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TranscriptomicsRNA-seq of brain mural cells and microvascular fragments
Purpose: Pericytes, the mural cells of blood microvessels, have come into focus as regulators of microvascular development and function, but due to paucity of defining markers, the identification and functional characterization of PC remain problematic, and reported data are often controversial. Her...
ORGANISM(S): Mus musculus 
2016-10-24 | E-GEOD-75668 | biostudies-arrayexpress
TranscriptomicsChanges in mouse kidney glomerular gene expression following dendrin knockout
Glomerular podocyte cells are critical for the function of the renal ultrafiltration barrier. The highly specialized cell-cell junction of podocytes, the slit diaphragm, has a central role in the filtration barrier. Dendrin is a poorly characterized cytosolic component of the slit diaphragm in where...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-47606 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A431 epidermoid carcinoma cells grown in media with antibodies against all three LN-332 chains to elucidate their molecular mechanisms of tumor growth inhibition
To elucidate the molecular mechanisms of tumor growth inhibition caused by the anti-LN-332 antibodies, we plated human A431 cells on plates coated with fibroblast-derived matrix for 6 hours and then added a mixture of antibodies against all three LN-332 chains or control IgG to the medium for 16 hou...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-MEXP-1141 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of mouse glomerulus in lipopolysaccharide-induced proteinuria model
The pathogenic mechanisms of common kidney glomerular diseases, including the vast majority of cases of proteinuria, remain unknown. To gain insight into the pathogenesis of proteinuria development, we characterized the glomerular gene expression changes that accompany early stages of proteinuria in...
ORGANISM(S): Mus musculus 
2009-08-25 | E-GEOD-12599 | biostudies-arrayexpress
TranscriptomicsMicroarray data from control and pericyte-deficient mouse brain microvascular transcriptomes
The blood-brain barrier (BBB) consists of specific physical barriers, enzymes and transporters, which together maintain the necessary extracellular environment of the central nervous system (CNS). The main physical barrier is found in the CNS endothelial cell, and depends on continuous complexes of ...
ORGANISM(S): Mus musculus 
2010-10-21 | E-GEOD-15892 | biostudies-arrayexpress
ProteomicsProteome profiling of the blood brain barrier in mice
To characterize the vascular proteome of the brain, proteins were extracted from the brain microvascular fragments isolated from adult mice using CD31-coated magnetic beads. The proteins were enzymatically digested and subjected to mass spectrometric analysis
ORGANISM(S): Mus Musculus (mouse) 
2026-08-07 | PXD071189 | JPOST Repository
TranscriptomicsVEGFR2 Y949F (lung RNAseq - mice)
RNA sequencing of lung tissue from transgenic mice in order to investigate the effect of a single tyrosine to phenylalanine exchange in the endothelial receptor VEGFR2 at position Y949. This exchange creates a mouse with unleaky blood vessels which is an advantage in several diseases such as cancer ...
ORGANISM(S): Mus musculus 
2020-06-12 | E-MTAB-9163 | biostudies-arrayexpress
TranscriptomicsGene expression changes in brain vascularture in Notch3 knockout mice
Vascular smooth muscle cells (VSMC) are important for contraction, blood flow distribution and regulation of blood vessel diameter, but to what extent they contribute to the integrity of blood vessels and blood-brain barrier function is less well understood. In this report, we explored the impact of...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-55203 | biostudies-arrayexpress
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