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TranscriptomicsBID is critical for IFN-alpha-induced cell death
Clinical applications of human interferon (IFN)-alpha have met with varying degrees of success. Nevertheless, key molecules in IFN-alpha-induced cell death have not been clearly identified. Our previous study indicated that IFN (alpha, beta and omega) receptor (IFNAR) 1/2- and IFN regulatory factor ...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-GEOD-29790 | biostudies-arrayexpress
TranscriptomicsAnalysis of the inflammatory transcription profiles of WT and Bid microglia
Apoptosis is a controlled cell-death process mediated inter alia by proteins of the Bcl-2 family. Some proteins previously shown to promote the apoptotic process were found to have non-apoptotic functions as well. Microglia, the resident immune cells of the central nervous system, respond to brain d...
ORGANISM(S): Mus musculus 
2010-09-01 | E-GEOD-18108 | biostudies-arrayexpress
TranscriptomicsStage-specific expression of TNFM-NM-1 regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells
Infectious pancreatic necrosis virus (IPNV) is a fish-derived pathogen and possess a bi-segmented, double-stranded RNA genome. By using zebrafish 14K oligo-microarray and quantitative RT-PCR, we identified differential expression of a defined subset of genes involved in apoptosis and immunity at 6-,...
ORGANISM(S): Danio rerio 
2011-02-01 | E-GEOD-21077 | biostudies-arrayexpress
TranscriptomicsDifferential Expression of Skeletal Muscle Genes Following Admnistration of Clenbuterol to Exercised Horses
Background: Clenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may also have repartitioning affects in horses and as such the potential to affect...
ORGANISM(S): Equus caballus 
2016-03-24 | E-GEOD-79559 | biostudies-arrayexpress
TranscriptomicsThe effect of alcohol on the expression of miroRNAs in rat nucleus accumbens
MicroRNAs (miRNAs) are small non-coding RNAs with strong biological functions. However, the roles of miRNAs in alcohol addiction are still unclear. In this study, we analyzed miRNA profile of in the nucleus accumbens (NAc) of rats treated with alcohol. The results demonstrated, among the 300 detect...
ORGANISM(S): Rattus norvegicus 
2013-08-01 | E-GEOD-47943 | biostudies-arrayexpress
TranscriptomicsBID is critical for IFN-alpha-induced cell death
Clinical applications of human interferon (IFN)-alpha have met with varying degrees of success. Nevertheless, key molecules in IFN-alpha-induced cell death have not been clearly identified. Our previous study indicated that IFN (alpha, beta and omega) receptor (IFNAR) 1/2- and IFN regulatory factor ...
ORGANISM(S): Homo sapiens 
2012-05-22 | GSE29790 | GEO
TranscriptomicsTranscription profiling of human dendritic cells exposed to microfilariae of Brugia Malayireveals induction of trail and TNF-alpha-dependent apoptosis
Dysregulation of professional APC has been postulated as a major mechanism underlying Ag-specific T cell hyporesponsiveness in patients with patent filarial infection. To address the nature of this dysregulation, dendritic cells (DC) and macrophages generated from elutriated monocytes were exposed ...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12787 | biostudies-arrayexpress
UnknownProapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress.
Not available
S-EPMC3074003 | biostudies-literature
ProteomicsA bacterial effector manipulates host lysosomal protease activity-dependent plasticity in cell death modalities to facilitate infection
Crosstalk between cell death programs confers appropriate host anti-infection immune responses, but how pathogens remodel this network to facilitate their infections remain largely unclear. Here, we identify mammalian cell entry 3C (Mce3C) as a key regulator of host cell death from Mycobacterium tub...
ORGANISM(S): Homo sapiens (Human) Mycobacterium tuberculosis 
2025-01-27 | PXD041707 | Pride
Mycobacteria tuberculosis Secreated protein Mce3c 
UnknownTax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression.
Not available
S-EPMC4649845 | biostudies-literature
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