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TranscriptomicsExpression data from 786-O renal cell cancer cells treated with pentamidine
While early stages of clear cell renal cell carcinoma (ccRCC) are curable, survival outcome for metastatic ccRCC remains poor. The purpose of the current study was to apply a new individualized bioinformatics analysis (IBA) strategy to these transcriptome data in conjunction with Gene Set Enrichment...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-54709 | biostudies-arrayexpress
TranscriptomicsGenomic Counter-Stress Changes Induced by Mind-Body Practice
Mind-body practices that elicit the relaxation response (RR) have been used worldwide for millennia to prevent and treat disease. The RR is believed to be the counterpart to stress response and is characterized by decreased oxygen consumption, increased exhaled nitric oxide, and reduced psychologica...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-10041 | biostudies-arrayexpress
TranscriptomicsGene expression changes during resistance toward vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI) therapy in renal cell carcinoma (RCC)
This study was performed to understand the gene expression changes that accompany treatment of renal cell carcinoma (RCC) with vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor (TKI) therapy. Human RCC cell lines were implanted into the flanks of nude beige mice, allowed...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-64052 | biostudies-arrayexpress
TranscriptomicsPML regulates PPAR signaling and fatty acid oxidation in breast cancer
Cancer cells exhibit an aberrant metabolism which facilitates more efficient production of biomass, and hence tumor growth and progression. The genetic cues modulating this metabolic switch remain largely undetermined, however. Here we identify a metabolic function for PML which reveals an unexpecte...
ORGANISM(S): Mus musculus 
2013-01-29 | E-GEOD-39220 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of RPMI8226 cells after knockdown of KDM3A and KLF2
Recent studies have implicated KDM3A, which catalyzes removal of H3K9 methylation, is associated with tumorigenesis. However, the biological role of KDM3A in multiple myeloma, has not been delineated. Here we identify KDM3A-KLF2-IRF4 axis dependence in multiple myeloma. We demonstrate that knockdown...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-55667 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Endothelial (EC) and Non-endothelial Cells
Gene expression profiling of HUVEC (human umbilical vein EC cell; Lonza), HAEC (human aortic EC cells), HCAEC (human coronary artery EC cells), HPAEC (human pulmonary artery EC cells), HMVEC (human microvascular (dermal) , HASMC ( Human Aortic Smooth Muscle Cells), T cells and Bcells. Gene expressio...
ORGANISM(S): Homo sapiens 
2011-04-04 | E-GEOD-21212 | biostudies-arrayexpress
TranscriptomicsExpression data from peritoneal biopsies of patients with encapsulating peritoneal sclerosis, patients undergoing first implantation of a peritoneal dialysis catheter, and patients undergoing abdominal surgery for non-peritoneal conditions
Expression data from peritoneal biopsies of patients with encapsulating peritoneal sclerosis (EPS), patients undergoing first implantation of a peritoneal dialysis catheter (PD), and patients undergoing abdominal surgery for non-peritoneal conditions (controls) We used microarrays to determine the t...
ORGANISM(S): Homo sapiens 
2014-11-04 | E-GEOD-62928 | biostudies-arrayexpress
TranscriptomicsThe role for TNF-alpha in murine type 1 and 2 diabetes
To search for new therapeutic targets for type 1 & 2 diabetes, we have applied genome wide transcriptional profiling and systems biology oriented bioinformatics analysis to examine the impact of the Power mix(PM) and Alpha-1 Anti-Trypsin( AAT) regimens upon pancreatic lymph node (PLN) and fat, a cru...
ORGANISM(S): Mus musculus 
2012-11-22 | E-GEOD-33891 | biostudies-arrayexpress
TranscriptomicsExpression profiling of murine neonatal lung tissue from Carm1 knockouts and wild type controls
Coactivator associated arginine methyltransferase I (CARM1, also known as Protein aRginine MethylTransferase 4, or PRMT4) regulates gene expression by multiple mechanisms including methylation of histones and coactivation of steroid receptor transcription. Mice lacking CARM1 are smaller than their l...
ORGANISM(S): Mus musculus 
2010-07-07 | E-GEOD-21606 | biostudies-arrayexpress
ProteomicsMechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine
Proteomic and single-cell RNAseq analyses reveal that GPH treatment upregulates autophagy and ER stress-related transcripts.
ORGANISM(S): Mus Musculus 
2024-11-20 | PXD058067 |
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