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TranscriptomicsTranscript profile comparison of Zbtb20-sufficient and Zbtb20-deficient polyclonal bone marrow plasma cells
ZBTB20 is an adjuvant-specific factor for long-term antibody responses. This factor is critical for maintaining long-lived plasma cells in alum-adjuvanted antibody responses but is dispensable for TLR ligand-adjuvanted responses. To identify the functions of ZBTB20 in long-lived plasma cells, we per...
ORGANISM(S): Mus musculus 
2014-06-19 | E-GEOD-58659 | biostudies-arrayexpress
TranscriptomicsTrancriptional comparison of Zbtb32-deficient and -sufficient cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-83194 | biostudies-arrayexpress
TranscriptomicsPlasma cell mitochondrial pyruvate import controls the duration of humoral immunity.
RNA-sequencing was performed on human CD19- CD138+ bone marrow plasma cells. 4 biological replicates of human CD19- CD138+ bone marrow plasma cells.
ORGANISM(S): Homo sapiens 
2016-05-14 | E-GEOD-81443 | biostudies-arrayexpress
TranscriptomicsTrancriptional comparison of Zbtb32-deficient and -sufficient polyclonal resting memory B cells
Memory B cell responses are more rapid and of greater magnitude than are primary antibody responses. The mechanisms by which these secondary responses are eventually attenuated remain unknown. We demonstrate that the transcription factor ZBTB32 limits the rapidity and duration of antibody recall res...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-83191 | biostudies-arrayexpress
TranscriptomicsTrancriptional comparison of Zbtb32-deficient and -sufficient NP-specific memory B cells at day 7 of recall response [BMPC]
Memory B cell responses are more rapid and of greater magnitude than are primary antibody responses. The mechanisms by which these secondary responses are eventually attenuated remain unknown. We demonstrate that the transcription factor ZBTB32 limits the rapidity and duration of antibody recall res...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-83193 | biostudies-arrayexpress
TranscriptomicsTrancriptional comparison of Zbtb32-deficient and -sufficient NP-specific memory B cells at day 7 of recall response [memory B cells]
Memory B cell responses are more rapid and of greater magnitude than are primary antibody responses. The mechanisms by which these secondary responses are eventually attenuated remain unknown. We demonstrate that the transcription factor ZBTB32 limits the rapidity and duration of antibody recall res...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-83190 | biostudies-arrayexpress
UnknownTranscriptional profiling of antigen-dependent murine B cell differentiation and memory formation.
Not available
S-EPMC4517294 | biostudies-literature
TranscriptomicsIRF-8 extinguishes neutrophil production and promotes dendritic cell lineage commitment in both myeloid and lymphoid progenitors (Affymetrix).
While most blood lineages are assumed to mature through a single cellular and developmental route downstream of hematopoietic stem cells (HSCs), dendritic cells (DCs) can be derived from both myeloid and lymphoid progenitors in vivo. To determine how distinct progenitors can generate similar downst...
ORGANISM(S): Mus musculus 
2012-01-07 | E-GEOD-34892 | biostudies-arrayexpress
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