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35 paired samples from initial diagnosis and first marrow relapse. Genes and pathways differentiating diagnosis and relapse were identified. Potential therapeutic targets were also identified. Experiment Overall Design: 35 patients with samples from initial diagnosis and first marrow relapse.
ORGANISM(S): Homo sapiens 
This SuperSeries comprises the following subset Series:; GSE3910: 35 patients at diagnosis and relapse; GSE3911: 60 samples obtained at relapse Experiment Overall Design: Refer to individual Series
ORGANISM(S): Homo sapiens 
Gene expression profiles were analyzed from 60 children with first bone marrow relapse. Genes and pathways differentiating early vs. late relapse were identified. Signatures predicting early response to therapy were also identified. Experiment Overall Design: 60 patients at relapse were analyzed
ORGANISM(S): Homo sapiens 
The cure rate for childhood ALL has improved considerably in part because therapy is routinely tailored to the predicted risk of relapse. Various clinical and laboratory variables are used in current risk-stratification schemes, but many children who fail therapy lack adverse prognostic factors at i...
ORGANISM(S): Homo sapiens 
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