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TranscriptomicsA methyl-deviator epigenotype of estrogen-receptor-positive breast carcinoma is associated with malignant biology
We broadly profiled DNA methylation in breast cancers (n=351) and benign parenchyma (n=47) for correspondence with disease phenotype using formalin-fixed paraffin-embedded (FFPE) diagnostic surgical pathology specimens. Exploratory analysis revealed a distinctive primary invasive carcinoma subclass ...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-29428 | biostudies-arrayexpress
TranscriptomicsApplication of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution.
5-hydroxymethylcytosine (5hmC), an oxidized derivative of 5-methylcytosine (5mC), has been implicated as an important epigenetic regulator of mammalian development. Current procedures use cost-prohibitive DNA sequencing methods to discriminate 5hmC from 5mC, limiting their accessibility to the scie...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-GEOD-60225 | biostudies-arrayexpress
no omics definedChromatin immunoprecipitation of human breast cancer cell line MCF-7 treated with 17beta-estradiol
ChIP-DSL experiments using ER alpha antibody on v1 20k promoter array
ORGANISM(S): Homo sapiens 
2007-03-31 | E-MEXP-984 | biostudies-arrayexpress
no omics definedTranscription profiling of human MCF7 estradiol treated cells sampled at 0h, 3h, 6h, 12h, 24h after treatment identifies an extensive ER-alpha binding program on human gene promoters
Gene expression experiments using the Illumina Human Ref8 whole genome expression array system. MCF7 cells were treated with estradiol and then used for expression experiments at specific timepoints after treatment (0h, 3h, 6h, 12h, 24h).
ORGANISM(S): Homo sapiens 
2007-04-01 | E-TABM-231 | biostudies-arrayexpress
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