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ProteomicsHCMV deletion models enable the identification of physiologically relevant T-cell epitopes
In healthy individuals, immune control of persistent human cytomegalovirus (HCMV) infection is effectively mediated by virus-specific CD4+ and CD8+ T cells. However, identification of the repertoire of T-cell specificities for HCMV is hampered by the immense protein coding capacity of this betaherpe...
ORGANISM(S): Homo sapiens (Human) Cytomegalovirus 
2019-11-20 | PXD013120 | Pride
Hla Hla ligandomics T-cell epitopes Human cytomegalovirus Immunoevasin deletion Immunotherapy Mhc affinity prediction 
ProteomicsMulti-omics discovery of exome-derived neoantigens in hepatocellular carcinoma
HLA class I ligandome dataset obtained from hepatocellular carcinoma (HCC) as well as corresponding adjacent benign liver tissue (n=16) characterizing respective HLA immunoprecipitates. Additionally, from a subset of the mentioned HCC/ adjacent benign liver samples datasets gained from shotgun prote...
ORGANISM(S): Homo sapiens (Human) 
2019-05-06 | PXD013057 | Pride
Hla Hla ligandomics Multi-omics Peptide prediction Mass spectrometry Personalized medicine Immunoinformatics Next-generation sequencing Immunotherapy Hepatocellular carcinoma Neoantigen Liver cancer 
ProteomicsMHCquant: Automated and reproducible data analysis for immunopeptidomics
Personalized multi-peptide vaccines are currently being discussed intensively for tumor immunotherapy. In order to find epitopes - short, immunogenic peptides - suitable to elicit an immune response, human leukocyte antigen-presented peptides from cancer tissue samples are purified using immunoaffin...
ORGANISM(S): Homo sapiens (Human) 
2019-10-14 | PXD011628 | Pride
Human Mhc Benchmark 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-31 | MSV000096271 | MassIVE
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