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TranscriptomicsNKp44/HLA-DP-dependent regulation of CD8 T cell clonality by NK cells
NK cells are increasingly recognized for their modulation of adaptive T cell responses; however the mechanisms by which NK cells modulate immune responses in human are unclear. Here we report that NKp44+ NK cells regulate CD8+ T cell expansion in an HLA-DP haplotype-dependent process. HLA-DP express...
ORGANISM(S): Homo sapiens 
2025-10-10 | E-MTAB-13405 | biostudies-arrayexpress
TranscriptomicsPro-tumorigenic effects of HLA-G in Renal Cell Carcinoma
Renal cell carcinoma (RCC) frequently exhibits high expression of the immunomodulatory molecule HLA-G, which promotes immune tolerance and tumor progression. To define the cell-intrinsic transcriptional programs driven specifically by HLA-G1 neo-expression, we generated RCC7/HLA-G1 cells by lentivir...
ORGANISM(S): Homo sapiens 
2026-05-01 | E-MTAB-16395 | biostudies-arrayexpress
ProteomicsThe HLA ligandome comprises a limited repertoire of O-GlcNAcylated antigens preferentially associated with HLA-B07:02
Mass-spectrometry based immunopeptidomics has provided unprecedented insights into antigen presentation, not only charting an enormous ligandome of self-antigens, but also cancer neo-antigens and peptide antigens harbouring post-translational modifications. Here we concentrate on the latter, focusin...
ORGANISM(S): Homo sapiens (Human) 
2021-12-03 | PXD028874 | Pride
O-glcnacylation Hla-b07 Mhc Hla class i Immunopeptidomics 
ProteomicsThe landscape of the SARS-CoV-2 HLA-peptidome
The human leukocyte antigen (HLA)-bound-viral antigens, serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of viral presented antigens. Utilizing HLA-peptidomics we Identified SARS-CoV-2-der...
ORGANISM(S): Homo sapiens (Human) 
2021-06-28 | PXD025499 | Pride
Sars-cov-2 Immunopeptidomics Hla-peptidomics 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
The human leukocyte antigen (HLA) complex regulates the adaptive immune response by showcasing the intracellular and extracellular protein content to the immune system. T cells recognize these HLA-presented peptides as self or foreign and can elicit an immune response. In this work, we describe the...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD019643 | Pride
Human Hla Benign tissues Immunopeptidomics 
ProteomicsThe HLA-Ligand-Atlas. A resource of natural HLA ligands presented on benign tissues
A use case of the benign HLA-Ligand-Atlas is the prioritization of tumor-associated targets for e.g. peptide vaccination. Based on three glioblastoma samples, we illustrated how many of these peptides are covered in the benign dataset. The experimental and computational workflow for the isolation an...
ORGANISM(S): Homo sapiens (Human) 
2021-04-16 | PXD020186 | Pride
Human Hla Glioblastoma Immunopeptidomics 
ProteomicsUnsupervised mining of HLA-I peptidomes reveals unsuspected false positives and new binding motifs
Modern antigen vaccine designs and studies of human leukocyte antigen (HLA)-mediated immune responses rely heavily on the knowledge of HLA allele-specific binding motifs and computational prediction of antigen-HLA binding affinity. Breakthroughs in HLA peptidomics have considerably expanded the data...
ORGANISM(S): Homo sapiens (Human) 
2021-09-17 | PXD028088 | Pride
Smsnet Peptidome Hla-i 
ProteomicsFully unsupervised identification of HLA-I motifs
The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and cancer. Here, by exploiting co-occurrence of HLA-I alleles across publicly available as well as ten...
ORGANISM(S): Homo sapiens (Human) 
2017-08-18 | PXD005231 | Pride
Hla peptidome Immunopeptidomics Lc-ms/ms 
ProteomicsTemperature induced change of the HLA ligandome
Temperature induced change of the HLA ligandome and proteome in B-cells
ORGANISM(S): Homo sapiens (Human) 
2021-05-07 | PXD022930 | Pride
Hla class ii ligandome Hla class i ligandome Immunopeptidome Proteome Lc-ms/ms 
ProteomicsA TCR blocking HLA-A*11:01-specific human monoclonal antibody
Cross-linking mass spectrometry and Targeted cross-linking mass spectrometry for a TCR blocking human monoclonal antibody targeting HLA-A*11:01
ORGANISM(S): Homo Sapiens (human) 
2025-06-02 | PXD053836 | JPOST Repository
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