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ProteomicsUnsupervised mining of HLA-I peptidomes reveals unsuspected false positives and new binding motifs
Modern antigen vaccine designs and studies of human leukocyte antigen (HLA)-mediated immune responses rely heavily on the knowledge of HLA allele-specific binding motifs and computational prediction of antigen-HLA binding affinity. Breakthroughs in HLA peptidomics have considerably expanded the data...
ORGANISM(S): Homo sapiens (Human) 
2021-09-17 | PXD028088 | Pride
Smsnet Peptidome Hla-i 
ProteomicsArginine (di)methylated Human Leukocyte Antigen class I peptides are favorably presented by HLA-B*07
Specific alterations in protein post-translational modification (PTMs) are recognized hallmarks of diseases. These modifications potentially provide a unique disease-related source of Human Leukocyte Antigen (HLA) class I-presented peptide antigens that can elicit specific immune responses. Although...
ORGANISM(S): Homo sapiens (Human) 
2016-08-15 | PXD004233 | Pride
Methylation Dimethylation Ethcd Hla-class i 
ProteomicsImmunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics
Tumor antigens are central to antitumor immunity. Recent evidence suggests that peptides from non-canonical (nonC) aberrantly translated proteins can be presented on HLA-I by tumor cells. Here, we investigated the presentation and immunogenicity of nonC antigens across different cancer types to bett...
ORGANISM(S): Homo sapiens (Human) 
2023-02-03 | PXD036856 | Pride
Human Non-canonical hla-i ligands 
Proteomicsthe landscape of phosphorylated HLA-I ligands
The identification and prediction of HLA-I–peptide interactions play an important role in our understanding of antigen recognition in infected or malignant cells. In cancer, non-self HLA-I ligands can arise from many different alterations, including non-synonymous mutations, gene fusion, cancer-spec...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD013831 | Pride
Immunopeptidomics Hla binding peptides Phosphorylations 
ProteomicsMultimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning
HLA class I (HLA-I) molecules play a central role for both NK and T-cell responses that prevent serious human cytomegalovirus (HCMV) disease. To create opportunities for viral spread, multifaceted HCMV-encoded immunoevasins target HLA-I. Among these, the glycoprotein US10 is so far insufficiently st...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD051190 | Pride
Antigen presentation Immune evasion Human cytomegalovirus 
ProteomicsHepG2 HLA-I immunopeptidome by immunoprecipitation
This study utilized mass spectrometry-based proteogenomic profiling to identify the HLA-I immunopeptidome enriched from HepG2 cell. HepG2 WES-based and the COSMIC-based mutation database were generated and utilized to identify HepG2-specific mutant immunopeptides
ORGANISM(S): Homo Sapiens 
PXD045203 |
ProteomicsHLA-I peptidomics od Meningioma tissues - Peptide length distribution and multiple specificity in naturally presented HLA-I ligands
HLA-I molecules bind short peptides and present them to CD8+ T cells for TCR recognition. The length of HLA-I ligands typically ranges from 8 to 12 amino acids, but high variability is observed between different alleles. Here we used recent HLA peptidomics data to analyze in an unbiased way peptide ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-31 | PXD009925 | Pride
Hla binding motifs Hla class i peptides Meningioma 
ProteomicsFully unsupervised identification of HLA-I motifs
The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and cancer. Here, by exploiting co-occurrence of HLA-I alleles across publicly available as well as ten...
ORGANISM(S): Homo sapiens (Human) 
2017-08-18 | PXD005231 | Pride
Hla peptidome Immunopeptidomics Lc-ms/ms 
ProteomicsIdentification of novel HLA class I-restricted hepatitis B virus peptides and their modulation by peptide editor TAPBPR
Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma and infections remain a substantial global health problem for which no curative therapy exists. As cytotoxic CD8+ T lymphocytes are the principal effectors of natural HBV resolution, there is considerable interest in discoverin...
ORGANISM(S): Homo sapiens (Human) 
2026-07-15 | PXD078020 | Pride
Immunopeptidomics Hla Tapbpr Mhc 
ProteomicsIntra-patient clonal diversity in HLA class I peptide ligand presentation
Tumor heterogeneity results from clonal diversity and evolutionary selection, and is a major cause of therapeutic resistance. Immunotherapy may exploit alternative vulnerabilities of drug resistant cells, and tumor-specific HLA peptide ligands on the cell surface are promising leads to invoke such t...
ORGANISM(S): Homo sapiens (Human) 
2020-10-26 | PXD016582 | Pride
Hla class i peptide ligands  colorectal cancer  tumor heterogeneity  patient-derived organoids  mass spectrometry  affinity proteomics 
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