Dimethylation - OmicsDI

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NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming

This SuperSeries is composed of the following subset Series: GSE29146: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [ChIP] GSE29147: NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [RNAi] GSE29148: NSD2 links dimethylation of histone H3 at...

ORGANISM(S): Homo sapiens

2011-11-29 | E-GEOD-29305 | biostudies-arrayexpress

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [RNAi]

NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...

ORGANISM(S): Homo sapiens

2011-11-29 | E-GEOD-29147 | biostudies-arrayexpress

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [Transduction]

ORGANISM(S): Mus musculus

2011-11-29 | E-GEOD-29150 | biostudies-arrayexpress

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [TKO]

ORGANISM(S): Homo sapiens

2011-11-29 | E-GEOD-29148 | biostudies-arrayexpress

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [ChIP]

ORGANISM(S): Homo sapiens

2011-11-29 | E-GEOD-29146 | biostudies-arrayexpress

Repression of PRMT5-mediated dimethylation stabilizes vimentin and promotes metastasis in MTAP-loss lung cancer

Abstract The aggressive nature and poor prognosis of lung cancer led us to explore the mechanisms driving disease progression. Utilizing our invasive cell-based model, we identified methylthioadenosine phosphorylase (MTAP) and confirmed its suppressive effects on tumorigenesis and metastasis, and pa...

ORGANISM(S): Homo sapiens (Human)

2022-05-31 | PXD031192 | Pride

Genome wide mapping of histone 3 lysine 79 dimethylation in MLL rearranged and control human leukemia cell lines

We report the genome wide distribution of H3K79 dimethylation in the human MLL-AF6 rearranged cell line ML2 as well as the human MOLM13 and HL60 cell lines Examination of H3K79 dimethylation in the MLL-AF6 fusion positive human leukemia cell line ML2 and control cell lines MOLM-13 and HL60. The MLL...

ORGANISM(S): Homo sapiens

2013-04-03 | E-GEOD-43063 | biostudies-arrayexpress

Genome wide mapping of histone 3 lysine 79 dimethylation in MLL-AF6 murine leukemias

We report the genome wide distribution of H3K79 dimethylation in mouse MLL-AF6 positive leukemias to assess whether this epigenetic mark drives MLL-target gene expression. Examination of H3K79 dimethylation in bone marrow cells from sacrificed terminally ill MLL-AF6 positive leukemic mice. The retr...

ORGANISM(S): Mus musculus

2013-04-03 | E-GEOD-43062 | biostudies-arrayexpress

Antibody-Free Profiling of Lysine Dimethylation via Chemoselective OxidationCoupled Reversible Enrichment

Lysine dimethylation (Kme2) is a critical post-translational modification (PTM), while its comprehensive analysis remains challenging due to low stoichiometry and lack of pan-specific antibodies. Here, we developed an antibody-free proteomics strategy combining selective fluorine-mediated oxidation ...

ORGANISM(S): Homo Sapiens

PXD078472 |

Structural insights into protein arginine symmetric dimethylation by PRMT5.

Not available

S-EPMC3251124 | biostudies-literature

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