Sort   by:  
 Page size 
ProteomicsHepG2 HLA-I immunopeptidome by immunoprecipitation
This study utilized mass spectrometry-based proteogenomic profiling to identify the HLA-I immunopeptidome enriched from HepG2 cell. HepG2 WES-based and the COSMIC-based mutation database were generated and utilized to identify HepG2-specific mutant immunopeptides
ORGANISM(S): Homo Sapiens 
2023-09-07 | PXD045203 |
ProteomicsEditing the immunopeptidome of melanoma cells using a potent inhibitor of ER aminopeptidase 1
The efficacy of cancer immunotherapy, including treatment with immune-checkpoint inhibitors, is often limited by ineffective presentation of antigenic peptides that can elicit T-cell mediated anti-tumor cytotoxic responses. Therefore, manipulating antigen presentation is an emerging approach for enh...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD011766 | Pride
Inhibitor Immunopeptidome Erap1 
ProteomicsLC-MSMS of the MHC-I immunopeptidome of AML cell lines
The hypomethylating agent 5-azacytidine (AZA) is the first-line induction therapy for AML patients unsuitable for intensive chemotherapy. The anti-tumor effect of AZA results in part from T-cell cytotoxic responses against MHC-I-associated peptides (MAPs) deriving from hypermethylated genomic region...
ORGANISM(S): Homo sapiens (Human) 
2024-04-17 | PXD038663 | Pride
Acute myeloid leukemia Eres 5-azacitidine Immunopeptidome Mhc-i 
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-19 | PXD008733 | Pride
Tissue Mass spectrometry Mhc Immunopeptidome Map 
ProteomicsSILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor-treated and resistant tumor cells
The immunopeptidome is constantly monitored by T cells to detect foreign or aberrant HLA peptides. It is highly dynamic and reflects the current cellular state, enabling the immune system to recognize abnormal cellular conditions, such as those present in cancer cells. To precisely determine how cha...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054097 | Pride
Kinase inhibitor resistance Immunopeptidomics Cancer Mass-spectrometry Cryptic peptides Mapk signaling Melanoma Lc-ms/ms 
ProteomicsA tissue-based draft map of the murine MHC class I immunopeptidome
The array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the adaptive immune system, very lit...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-19 | MSV000084980 | MassIVE
ProteomicsImmunopeptidome on MC38 Cell line
PTM – driven antigenicity – immunopeptidome of MC38 cell line
ORGANISM(S): Mus musculus (Mouse) 
2022-10-12 | PXD017448 | Pride
Ptm Immunopeptidome 
ProteomicsKinase inhibition rewires the HLA-I immunopeptidome in Chronic Myeloid Leukemia
Antileukemia immunity is essential for disease control and maintaining treatment-free remission in chronic myeloid leukemia (CML). Immunotherapeutic approaches hold significant promise for enhancing immune-mediated disease control. However, successful immunotherapy relies on identifying CML-associat...
ORGANISM(S): Homo sapiens (Human) 
2026-06-01 | PXD076608 | Pride
Kinase inhibitors Immunopeptidomics Proteomics Cml 
ProteomicsImmunopeptidome of an acute myeloid leukemia cell line THP1
We report the use of complementary peptide antigen enrichment and comprehensive mass spectrometric acquisition strategies to provide in-depth immunopeptidome data for AML cell line THP1
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-09 | MSV000087786 | MassIVE
ProteomicsER stress and dsRNA sensing with Rt3D and palbociclib - Immunopeptidome
Cytoplasmic pattern recognition receptors (PRRs) for double-stranded RNA (RIG-I/MDA5) are key mediators of anti-viral responses. PRR agonists, such as dsRNA oncolytic Reovirus type 3 Dearing (Rt3D), potently activate RNA sensors. We used an unbiased cytotoxicity screen to reveal synergistic drug-vir...
ORGANISM(S): Homo sapiens (Human) 
2025-05-02 | PXD036559 | Pride
A375 Tmtpro Immunopeptidome 
Sort   by:  
 Page size