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TranscriptomicsProtoanemonin: A new natural quorum sensing inhibitor that selectively activates iron starvation response
Many Gram-negative bacteria employ cell-to-cell communication mediated by N-acyl homoserine lactones (quorum sensing) to control expression of a wide range of genes including, but not limited to, genes encoding virulence factors. Outside the laboratory, the bacteria live in complex communities where...
ORGANISM(S): Pseudomonas aeruginosa 
2012-06-12 | E-GEOD-27674 | biostudies-arrayexpress
TranscriptomicsIn-Vivo Expression Profiling of Pseudomonas aeruginosa Infections Reveals Niche-Specific and Strain-Independent Transcriptional Programs
Pseudomonas aeruginosa is a threatening, opportunistic pathogen causing disease in immunocompromised individuals. The hallmark of P. aeruginosa virulence is its multi-factorial and combinatorial nature. It renders such bacteria infectious for many organisms and it is often resistant to antibiotics. ...
ORGANISM(S): Pseudomonas aeruginosa 
2011-09-19 | E-GEOD-23007 | biostudies-arrayexpress
TranscriptomicsPAO1 gene expression at 22M-BM-0C and 37M-BM-0C in Lysogeny broth
Pseudomonas aeruginosa strain PAO1 was grown at 22M-BM-0C and 37M-BM-0C in Lysogeny broth (LB) and RNA was hybridized on the Affymetrix P. aeruginosa chip. PAO1 was grown in triplicate in Lysogeny broth at 22M-BM-0C or 37M-BM-0C. Total RNA from each sample was pooled and amplified then assayed in t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2014-01-01 | E-GEOD-51409 | biostudies-arrayexpress
TranscriptomicsPAHM4 vs PAO1 37C LB
Pseudomonas aeruginosa strains PAHM4 and PAO1 were grown at 37C on LB and RNA was hybridized on the Affymetrix P. aeruginosa chip to compare transcript differences from a BQ isolate to a well characterized wound isolate. Strains PAHM4 and PAO1 were grown in triplicate. Total RNA from each sample wa...
ORGANISM(S): Pseudomonas aeruginosa PAHM4 
2012-10-01 | E-GEOD-40461 | biostudies-arrayexpress
TranscriptomicsEx vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites
The opportunistic bacterium Pseudomonas aeruginosa is a major nosocomial pathogen causing both devastating acute and chronic persistent infections. During the course of an infection, P. aeruginosa rapidly adapts to the specific conditions within the host. In the present study, we aimed at the identi...
ORGANISM(S): Pseudomonas aeruginosa 
2012-11-14 | E-GEOD-25945 | biostudies-arrayexpress
TranscriptomicsCross-regulation between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa
Two-component systems (TCS) serve as basic stimulus-response coupling mechanisms to allow organisms to sense and respond to a large variety of environmental conditions. In the opportunistic pathogen Pseudomonas aeruginosa, more than 100 genes encode TCS components. To avoid unwanted cross-talk betwe...
ORGANISM(S): Pseudomonas aeruginosa UCBPP-PA14 
2015-06-08 | E-GEOD-64056 | biostudies-arrayexpress
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