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UnknownMapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2.
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S-EPMC9795807 | biostudies-literature
TranscriptomicsInactivation of the exosome ribonuclease DIS3 triggers the pluripotency factor LIN28B, repressing let-7 miRNAs and unleashing MYC and RAS.
Somatic mutations affecting DIS3, the catalytic component of the RNA exosome, have been found in up to 18% of patients affected by the hematological cancer multiple myeloma. Here we show that DIS3 targets and degrades the pluripotency factor LIN28B. In cancer cells, DIS3 inactivation leads to enhanc...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-GEOD-55246 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of MES-MM 98 and REN mesothelioma cell lines modulated for miR-24-3p expression
Identification of relevant miR-24-3p target mRNAs in human mesothelioma cell lines in order to characterize novel therapeutical targets in Mesothelioma disease
ORGANISM(S): Homo sapiens 
2019-02-13 | E-MTAB-7079 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Delta47 human myeloma cells expressing either the FNDC3A protein or a Mock control
Total RNAs were isolated from Delta47 human myeloma cells expressing either the FNDC3A protein or a Mock control and sequenced. The Delta47 cell line lacks FNDC3A expression, so the purpose of the experiment was to quantify the differentially-abundant mRNAs in the two cell lines.
ORGANISM(S): Homo sapiens 
2020-10-22 | E-MTAB-8496 | biostudies-arrayexpress
TranscriptomicsMicroarray of the multiple myeloma OPM2 cell line expressing either wt FAM46C or the FAM46C-D90G mutant allele
The aim of the analysis is to compare the trascriptome of myeloma cells expressing the wt version of novel oncosuppressor FAM46C comparing it with that of cells expressing a mutant variant of the same gene often found in patients (the D90G mutant allele) or to a Mock control. Cells were grown in RP...
ORGANISM(S): Homo sapiens 
2020-10-23 | E-MTAB-8188 | biostudies-arrayexpress
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