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MetabolomicsFrom Microbiota to Metabolomics: How Bifidobacterium infantis YLGB-1496 Shields Neonates from Necrotizing enterocolitis

Bifidobacterium species are recognized as essential primary colonizers of the infant gastrointestinal tract and constitute a critical component of infant formula. Nevertheless, the precise mechanisms by which Bifidobacterium confers its protective effects against gut inflammation remain insuffici...

2025-10-20 | MTBLS13018 | MetaboLights
MetabolomicsBifidobacterium bifidum-derived nanoparticles attenuate alcoholic liver disease via enhanced hepatic phagocytosis and gastrointestinal homeostasis
Alcohol-associated liver disease (ALD) has limited therapeutic options due to its complex pathogenesis. This study demonstrates the ALD-protective effects of extracellular nanoparticles derived from Bifidobacterium bifidum (BNPs), focusing on the novel concept of gut microbiota-derived nanoparticles...
2025-06-19 | MTBLS12612 | MetaboLights
TranscriptomicsCross-feeding by Bifidobacterium breve UCC2003 during Bifidobacterium bifidum PRL2010 growth on a mucin-based medium.
Bifidobacteria constitute commensal bacteria that commonly inhabit the mammalian gastro intestinal tract. The gut commensal Bifidobacterium breve UCC2003 was previously shown to utilise a variety of plant/diet-derived carbohydrates, including cellodextrin, starch and galactan. In the current study, ...
ORGANISM(S): Bifidobacterium breve UCC2003 
2014-12-17 | E-GEOD-59013 | biostudies-arrayexpress
TranscriptomicsDiscovering novel bile protection systems in Bifidobacterium breve UCC2003 through functional genomics
Tolerance of gut commensals to bile salt exposure is an important feature for their survival in and colonization of the intestinal environment. A transcriptomic approach was employed to study the response of Bifidobacterium breve UCC2003 to bile, allowing the identification of a number of bile-induc...
ORGANISM(S): Bifidobacterium breve UCC2003 
2011-12-16 | E-GEOD-31032 | biostudies-arrayexpress
MetabolomicsBifidobacterium animalis subsp. lactis BD1 restores neurotransmitter homeostasis in chronically stressed mice via tryptophan metabolic reprogramming

Background: Chronic psychological stress is a major precipitating factor for neuropsychiatric disorders, yet the underlying mechanisms remain incompletely understood. The gut-brain axis has emerged as a critical regulator of mood and behavior, but how specific commensal microbes modulate host neu...

2025-10-23 | MTBLS13208 | MetaboLights
TranscriptomicsTranscriptional regulation of the sialic acid utilization gene cluster of Bifidobacterium breve UCC2003 by a GntR-type transcriptional repressor.
Members of the genus Bifidobacterium are typically found in the gastrointestinal tract (GIT) of humans and other mammals. Bifidobacterium breve strains are numerically prevalent among the gut microbiota of healthy, breast-fed infants. The metabolism of sialic acid, a ubiquitous monosaccharide in the...
ORGANISM(S): Bifidobacterium breve UCC2003 
2015-03-05 | E-GEOD-62885 | biostudies-arrayexpress
TranscriptomicsA conserved two-component signal transduction system controls the response to phosphate starvation in Bifidobacterium breve UCC2003
This work reports on the identification and molecular characterization of a two-component regulatory system (2CRS), encoded by phoRP in Bifidobacterium breve UCC2003, which controls the response to phosphate (Pi) starvation. The response regulator PhoP was shown to bind to the promoter region of pst...
ORGANISM(S): Bifidobacterium breve UCC2003 
2012-09-06 | E-GEOD-34983 | biostudies-arrayexpress
MetabolomicsBifidobacterium animalis subsp. lactis V9 Overcomes CYFRA 21-1-Linked Immunochemotherapy Resistance in NSCLC via Microbial Metabolites

Elevated serum cytokeratin 19 fragment (CYFRA 21-1) marks aggressive disease

and poor response to immunochemotherapy in advanced non-small cell lung cancer

(NSCLC), but its link to gut microbiome dysfunction remains unclear. We show that

high CYFRA 21-1 levels correlate with dep...

2026-07-21 | MTBLS13296 | MetaboLights
MetabolomicsBifidobacterium animalis subsp. lactis V9 Overcomes CYFRA 21-1-Linked Immunochemotherapy Resistance in NSCLC via Microbial Metabolites

Elevated serum cytokeratin 19 fragment (CYFRA 21-1) marks aggressive disease

and poor response to immunochemotherapy in advanced non-small cell lung cancer

(NSCLC), but its link to gut microbiome dysfunction remains unclear. We show that

high CYFRA 21-1 levels correlate with dep...

2026-07-21 | MTBLS13300 | MetaboLights
MetabolomicsAntimicrobial Efficacy of Bifidobacterium longum FB1-4 Cell-Free Supernatant Against MRSA: Insights into Mechanisms and Food Matrix Application

The food safety landscape faces a significant challenge from methicillin-resistant Staphylococcus aureus (MRSA), a virulent and antibiotic-resistant foodborne pathogen. This study investigates the antimicrobial properties and mechanisms of cell-free supernatant (CFS) from Bifidobacterium longum F...

2026-02-26 | MTBLS13481 | MetaboLights
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