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TranscriptomicsComparison of Gene Expression in Psoriatic Skin from Different Sources
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-41664 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in psoriatic lesional and non-lesional skin [Set 1]
To explore the psoriasis phenotype, we characterize gene expression in lesional and non-lesional skin from psoriasis patients. We extracted total RNA from 5mm punch biopsies taken from 14 psoriatic patients. From each patient, we obtained two biopsies, one from a lesion and the other from non-lesion...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-34248 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in psoriatic lesional and non-lesional skin [Set 2]
To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients. From each of the 24 psoriasis patients, we obtained two biopsies, one from a lesion and the other from non-lesional skin in the same gene...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-41662 | biostudies-arrayexpress
TranscriptomicsRe-analysis by microarray using cDNA target of samples from psoriasis patients enrolled in an etanercept trial
cDNA and cRNA hybridization technologies have different, probe-specific sensitivities. We used samples from an etanercept trial (GSE11903) to explore in a real-life setting the uniqueness of each platform. We obtained total RNA for a subset of the samples in GSE11903 from Jim Krueger and generated e...
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-41663 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in psoriatic lesional and non-lesional skin [brodalumab treatment]
To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients. Furthermore, we explored the effects of various doses of brodalumab on lesional skin over time. From each of the 25 psoriasis patients, w...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-53552 | biostudies-arrayexpress
TranscriptomicsEffect of rBTNL2.Fc co-stimulation on murine CD4+ cells
Naïve T cell activation involves at least two signals from an antigen presenting cell (APC), one through the T cell receptor via interaction with APC peptide-MHC complexes and a second through interaction of CD28 with APC B7 ligands. Following activation, T cells up-regulate a host of other membran...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-42385 | biostudies-arrayexpress
TranscriptomicsTissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial
The objectives of this study were to measure effects of an aspirin intervention on gene expression in normal colonic epithelial and stromal tissue in healthy humans and to determine whether response differed by UGT1A6*2 genotype. We also sought to characterize gene expression differences within colo...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-71571 | biostudies-arrayexpress
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