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ProteomicsHuman gastric extracellular matrix hydrogels maintain organoid growth and reduce gene expression associated with epithelial-mesenchymal transition and inflammation
Human gastric organoids (HGOs) are 3-D cultures of primary gastric epithelial cells that serve as in vitro models for gastric epithelial physiology, development, and disease. The extracellular matrix material that organoids are maintained in provides crucial signals to the epithelial cells, regulat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD066286 | Pride
Decellularized tissue  gastric stroma  hydrogel  extracellular matrix 
ProteomicsPhysical, chemical, and structural properties of human gastric organoid-derived mucus
We explored the potential of human gastric organoids as models for mucus production. Immunofluorescence staining confirmed that the organoids produced mucus containing MUC5AC and MUC6. The luminal mucus had viscoelastic properties similar to those of native human gastric mucus, as determined by part...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2025-12-30 | PXD072060 | Pride
Gastric mucus layer  organoids  air-liquid interface  gastric epithelial barrier  microrheology  organoid lumen 
ProteomicsSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Infection of Jamaican Fruit Bat Intestinal Epithelial Cells Induces Robust Interferon Activation
Bats are the most important natural reservoirs for a variety of emerging viruses that cause several illnesses in humans and other mammals. Increased viral shedding by bats is thought to be linked to an increased ability of many bat species to tolerate viral infection. The severe acute respiratory sy...
ORGANISM(S): Artibeus jamaicensis 
2024-01-26 | PXD036016 | Pride
Sars-cov-2 Dia Interferon Jamaican fruit bats 
ProteomicsHuman gastric extracellular matrix hydrogels maintain organoid growth and reduce gene expression associated with stemness and inflammation
Human gastric organoids (HGOs) are 3-D cultures of primary gastric epithelial cells that serve as in vitro models for gastric epithelial physiology, development, and disease. The extracellular matrix material that organoids are maintained in provides crucial signals to the epithelial cells, regulat...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD081816 | Pride
Decellularized tissue  gastric stroma  hydrogel  extracellular matrix 
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