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MetabolomicsMetabolic network construction reveals probiotic-specific colonization resistance in a synthetic small intestinal community

The gut microbiota is essential to host health. Probiotics can be used as a microbiota targeted therapy to improve host health. However, probiotic molecular mechanisms of action and probiotics targeting the small intestinal microbiota are often not elucidated. In this study, we construct a three ...

2024-09-26 | MTBLS7370 | MetaboLights
MetabolomicsAlterations in the Gut Microbiota and Metabolomics of Seafarers after a Six-Month Sea Voyage

Maintaining the health of seafarers is a difficult task during long-term voyages. Little is known about the corresponding changes in the gut microbiome-host interaction. This study recruited 30 seafarers undertaking a 6-month voyage and analyzed their gut microbiota using 16S rRNA gene sequencing...

2022-09-29 | MTBLS5335 | MetaboLights
TranscriptomicsHigh-density deletion bin map of wheat D genome
A NimbleGen array containing both gene-based and RJM repeat junction probe sequences derived from Ae. Tauschii was developed and used to map the Chinese Spring nullisomic-tetrasomic lines and deletion bin lines of the D genome chromosomes. The NimbleGen array was hybridized in duplicate with Cy3 lab...
ORGANISM(S): Aegilops tauschii 
2015-07-22 | E-GEOD-71190 | biostudies-arrayexpress
MetabolomicsA microfluidics-based in vitro model of the gastrointestinal human-microbe interface
Changes in the human gastrointestinal microbiome are associated with several diseases. To infer causality, experiments in representative models are essential, but widely used animal models exhibit limitations. Here we present a modular, microfluidics-based model (HuMiX, human–microbial crosstalk), w...
2017-07-28 | MTBLS328 | MetaboLights
MetabolomicsCreation and Characterization of a Genomically Hybrid Strain in the Nitrogen-Fixing Symbiotic Bacterium Sinorhizobium meliloti
Many bacteria, often associated with eukaryotic hosts and of relevance for biotechnological applications, harbor a multipartite genome composed of more than one replicon. Biotechnologically relevant phenotypes are often encoded by genes residing on the secondary replicons. A synthetic biology approa...
2021-03-17 | MTBLS576 | MetaboLights
MetabolomicsBiodiversity in marine invertebrate responses to acute warming revealed by a comparative multi-omics approach
Understanding species' responses to environmental change underpins our abilities to make predictions on future biodiversity under any range of scenarios. In spite of the huge biodiversity in most ecosystems, a model species approach is often taken in environmental studies. To date, we still do not k...
2016-06-23 | MTBLS336 | MetaboLights
MetabolomicsA targeted MRM-based lipidomic dataset of Tenebrio molitor larvae fed diets with different protein levels
Tenebrio molitor is increasingly used as a sustainable source of nutrients for food and feed production, yet their lipid metabolic responses to dietary protein remain poorly characterized at the molecular species level. Here, we report a targeted UPLC–MS/MS lipidomics dataset of Tenebrio molitor lar...
2026-05-20 | MTBLS14531 | MetaboLights
MetabolomicsA robust method for performing 1H-NMR lipidomics in embryonic zebrafish
The embryonic zebrafish is an ideal system for lipid analyses with relevance to many areas of bioscience research, including biomarkers and therapeutics. Research in this area has been hampered by difficulties in extracting, identifying and quantifying lipids. We employed 1H-NMR at 700MHz to profile...
2024-07-02 | MTBLS2396 | MetaboLights
TranscriptomicsBIN-67 small cell ovarian carcinoma SNP array
The biology of small cell ovarian carcinoma of the hypercalcemic type (SCCOHT), which is a rare and aggressive form of ovarian cancer, is poorly understood. Tumourigenicity, in vitro growth characteristics, genetic and genomic anomalies, and sensitivity to standard and novel chemotherapeutic treatme...
ORGANISM(S): Homo sapiens 
2013-09-24 | E-MTAB-1584 | biostudies-arrayexpress
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
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