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Specific protein binders with high affinity, such as antibodies or nanobodies, are scarce for most solute carrier (SLCs) transporters. Moreover, general approaches that can systematically generate binders for multi-transmembrane proteins, such as SLCs, channels or GPCRs, are still missing. Purifying...
ORGANISM(S): Homo sapiens (Human) 
2024-06-17 | PXD046995 | Pride
The activation of the transcription factor NF-E2-related factor 2 (Nrf2) maintains cellular homeostasis in response to oxidative stress by the regulation of multiple cytoprotective genes. Without stressors the activity of Nrf2 is inhibited by its interaction with the kelch-like ECH-associated protei...
ORGANISM(S): Mus musculus 
The eight raw files starting with 'AGTRAP-comp' represent the chemoproteomics MS data of 10 μM IDRB-Probe-2 with multiple concentrations of competitive IDRB-Binder-2 in HEK-293. Each concentration includes three measurements taken from distinct samples. 126, 127N and 127C represent the data of 10 μM...
ORGANISM(S): Homo sapiens (Human) 
2026-05-06 | PXD077182 | Pride
The eight raw files starting with 'BASP1-comp' represent the chemoproteomics MS data of 3 μM IDRB-Probe-1 with multiple concentrations of competitive IDRB-Binder-1 in MCF-7. Each concentration includes three measurements taken from distinct samples. 126, 127N and 127C represent the data of 3 μM diaz...
ORGANISM(S): Homo sapiens (Human) 
2026-05-06 | PXD076393 | Pride
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