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MetabolomicsBioactive molecule(s) of gut bacteria of Crocodile (Crocodylus palustris) as potential pharmaceuticals
Not available
ORGANISM(S): Pseudomonas aeruginosa 
ST002447 | MetabolomicsWorkbench
MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
TranscriptomicsTranscription profiling of human osteoblasts differentiated from human mesenchymal stem cells and treated with three bioactive peptides
Effects of bioactive peptides IPP(Ile-Pro-Pro), VPP (Val-Pro-Pro), and LKP(Leu-Lys-Pro) on gene expression of osteoblast differentiated from human mesenchymal stem cells. Experimental design types: compound treatment and augmented reference design.
ORGANISM(S): Homo sapiens 
2008-01-23 | E-MEXP-885 | biostudies-arrayexpress
ProteomicsBioactive natural product peptide discovery in fungal secretoms using PepSAVI-MS
Fungal secondary metabolites represent a rich and largely untapped source for bioactive molecules, including peptides with substantial structural diversity and pharmacological potential. As methods proceed to take a deep dive into fungal genomes, complimentary methods to identify bioactive component...
ORGANISM(S): Ustilago maydis virus P4 
2018-02-19 | PXD006931 | Pride
Peptidomics Mass spectrometry Fungal secretome analysis Bioactive peptides 
ProteomicsDeciphering mechanism of actions of novel compounds by bioactive thermal proteome profiling
Exploring the therapeutic effects of bioactive compounds has been traditionally approaching by phenotypic screenings followed by functional validation by in vitro assays. The thermal proteome profiling (TPP) has been successfully applied to study drug targets and off-target. We applied a modified pr...
ORGANISM(S): Homo sapiens (Human) 
2019-06-28 | PXD013227 | Pride
Thermal proteome profiling  mechanism of actions  bioactive compound  label-free quantitative proteomics  marine biodiscovery 
ProteomicsExploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1
Background. As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance, new methods and innovative technologies are necessary to replenish our dwindling arsenal of antimicrobial agents. To this end, we developed the PepSAVI-MS pipeline to expedite the...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2018-07-23 | PXD009003 | Pride
Peptidomics Antimicrobial peptides (amps) Bacterial secretome Mass spectrometry Enterococcus faecalis Bioactive peptides Natural products 
TranscriptomicsExpression data from LPS-stimulated RAW 264.7 mouse macrophages treated with Hypericum perforatum fraction and bioactive constituents
Hypericum perforatum extracts have been used as dietary supplements to treat conditions including mild-moderate depression and inflammation. A group of four bioactive constituents were identified from an active fraction of the extract. In order to identify the mechanism for the potential anti-inflam...
ORGANISM(S): Mus musculus 
2010-05-28 | E-GEOD-21841 | biostudies-arrayexpress
GenomicsBioactive Compounds from Endophytic fungus Curvularia sorghina
Bioactive Compounds from Endophytic fungus Curvularia sorghina
PRJEB25627 | ENA
GenomicsBioactive peptides from Channa striatus
Exploration of bioactive peptides from innate immune molecules of Channa striatus
PRJEB25012 | ENA
ProteomicsPhytotoxic peptides released by the phytopathogenic fungus Botrytis cinerea as a potential novel mechanism of fungal infection
Botrytis cinerea, the causal agent of gray mold and noble rot, is a phytopathogenic fungus with a scientific and economic relevance due to its effects in agriculture. This fungus employs various molecular tools, such as enzymes and secondary metabolites, to infect and colonize plant tissues. Pathoge...
ORGANISM(S): Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) 
2026-06-04 | PXD065737 | Pride
Botrytis cinerea Bioactive peptides New phytotoxic tool Peptidome Lc-ms/ms 
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