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MetabolomicsAntioxidant Activity, Phytochemical Profiling by UPLC-QTOF-MS, and In Silico Targeting of the RNA-Binding Protein DRBD18 of Trypanosoma brucei by Bioactive Compounds from Tetradenia riparia and Tetracera poggei
Oxidative stress plays a key role in the pathogenesis of African trypanosomiasis, and plant-derived antioxidants represent a promising source of dual-action compounds capable of both scavenging reactive oxygen species and interfering with parasite survival. The present study investigates the antioxi...
2026-09-10 | MTBLS15597 | MetaboLights
GenomicsBioactive Compounds from Endophytic fungus Curvularia sorghina
Bioactive Compounds from Endophytic fungus Curvularia sorghina
PRJEB25627 | ENA
MetabolomicsEnhanced bioproduction of phenolic compounds from Populus nigra L. using temporary immersion bioreactors and metabolomics

Black poplar is a woody species rich in bioactive phenolic compounds with promising pharmaceutical and cosmetic applications. In wild populations, genetic diversity and environmental variability affect phenolic content and bioactivities. Plant tissue culture, conducted under controlled conditions...

2025-11-06 | MTBLS13131 | MetaboLights
MetabolomicsComparative analysis of whole plant, flower and root extracts of Chamomilla recutita L. and characteristic pure compounds reveals differential anti-inflammatory effects on human T cells

Introduction

Chronic inflammation is a hallmark of chronic wounds and inflammatory skin diseases. Due to a hyperactive and prolonged inflammation triggered by proinflammatory immune cells, transitioning to the repair and healing phase is halted. T cells may exacerbate the proinflammatory mil...
2025-07-09 | MTBLS9800 | MetaboLights
ProteomicsDeciphering mechanism of actions of novel compounds by bioactive thermal proteome profiling
Exploring the therapeutic effects of bioactive compounds has been traditionally approaching by phenotypic screenings followed by functional validation by in vitro assays. The thermal proteome profiling (TPP) has been successfully applied to study drug targets and off-target. We applied a modified pr...
ORGANISM(S): Homo sapiens (Human) 
2019-06-28 | PXD013227 | Pride
Thermal proteome profiling  mechanism of actions  bioactive compound  label-free quantitative proteomics  marine biodiscovery 
UnknownUnconventional Edible Plants of the Amazon: Bioactive Compounds, Health Benefits, Challenges, and Future Trends.
Not available
S-EPMC11431067 | biostudies-literature
TranscriptomicsExpression data from LPS-stimulated RAW 264.7 mouse macrophages treated with Hypericum perforatum fraction and bioactive constituents
Hypericum perforatum extracts have been used as dietary supplements to treat conditions including mild-moderate depression and inflammation. A group of four bioactive constituents were identified from an active fraction of the extract. In order to identify the mechanism for the potential anti-inflam...
ORGANISM(S): Mus musculus 
2010-05-28 | E-GEOD-21841 | biostudies-arrayexpress
ProteomicsExploring bioactive peptides from bacterial secretomes using PepSAVI-MS: identification and characterization of Bac-21 from Enterococcus faecalis pPD1
Background. As current methods for antibiotic drug discovery are being outpaced by the rise of antimicrobial resistance, new methods and innovative technologies are necessary to replenish our dwindling arsenal of antimicrobial agents. To this end, we developed the PepSAVI-MS pipeline to expedite the...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2018-07-23 | PXD009003 | Pride
Peptidomics Antimicrobial peptides (amps) Bacterial secretome Mass spectrometry Enterococcus faecalis Bioactive peptides Natural products 
TranscriptomicsTranscription profiling by array of yeast heterozygous diploid deletions strains screened with 20 compounds to identify gene deletions that confer sensitivity to each compound
The complete pool of barcoded essential heterozygous diploid deletion strains of S. cerevisiae were screened with 20 compounds from the Chembridge NOVACore chemical library to identify gene deletions that confer sensitivity to each compound.
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-13 | E-TABM-977 | biostudies-arrayexpress
MetabolomicsGNPS - Abagyan's lab bioactive compounds screening
GNPS - Abagyan's lab bioactive compounds screening
ORGANISM(S): Synthetical Compounds 
2019-02-26 | MSV000083490 | GNPS
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