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MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
MetabolomicsDeep longitudinal multi-omics analysis of Bordetella pertussis cultivated in bioreactors highlights medium starvations and transitory metabolisms, associated to vaccine antigen biosynthesis variations and global virulence regulation

Bordetella pertussis is the bacterial causative agent of whooping cough, a serious respiratory illness. An extensive knowledge on its virulence regulation and metabolism is a key factor to ensure pertussis vaccine manufacturing process robustness. The aim of this study was to refine our ...

2023-02-21 | MTBLS5762 | MetaboLights
MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
MetabolomicsA multi-omics approach to study peroxisome proliferator-activated receptor mediated regulation of lipid metabolism in Atlantic cod (Gadus morhua)
Lipid metabolism is essential in maintaining energy homeostasis in multicellular organisms. In vertebrates, a group of nuclear receptor transcription factors named peroxisome proliferator-activated receptors (PPARs, NR1C) regulate the expression of many genes involved in these processes. We have rec...
2022-02-28 | MTBLS2131 | MetaboLights
MetabolomicsInvestigating the Mechanisms of Silver Nanoparticle Toxicity in Daphnia magna: A Multi-Omics Approach
Silver nanoparticles (AgNPs), one of the most common nanomaterials in use today, have been shown to enter the aquatic environment from use of commercially obtained products. Although acute toxicity has been shown in vitro and in vivo, there is still a great deal of uncertainty surrounding the molecu...
2017-05-08 | MTBLS260 | MetaboLights
MetabolomicsRhizosphere Microbiome Assembly and Metabolic Reprogramming in Phallus rugulosus Revealed by Multi-Omics Integration
We conducted non-targeted metabolomic analysis on the rhizosphere and non-rhizosphere soils of Phallus rugulosus, using LC-MS to quantify metabolites, and compared the data from both to determine the differences in metabolites between the rhizosphere and non-rhizosphere of Phallus rugulosus.
2026-05-17 | MTBLS14504 | MetaboLights
MetabolomicsMulti-omics Elucidates Gut Microbiota-Driven Mechanisms of Lipid Deposition in Pigs Fed a DDGS Diet

Abstract:

Background: Corn dried distillers’ grains with solubles (DDGS) is a cost-effective alternative feed ingredient in swine diets. However, its negative impact on carcass fat quality, characterized by increased polyunsaturated fatty acids (PUFAs) and reduced fat firmness, fundamentall...

2026-03-16 | MTBLS14058 | MetaboLights
MetabolomicsIntegrated Multi-omics Analysis of Human Biliary Organoids Reveals Dysregulated Metabolic and Fibro-Inflammatory Programs in Biliary Atresia
Human intrahepatic biliary organoids were established from liver tissues of children with BA (n = 11), choledochal cysts (CC, n = 5), and histologically normal controls (NC, n = 5). We performed comprehensive multi-omics profiling, including transcriptomics, proteomics, phosphoproteomics, and untarg...
2026-09-02 | MTBLS15528 | MetaboLights
MetabolomicsCell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle since the insect stage utilizes the cost-effective oxidative phosphorylation to generate ATP, while bloodstream cells switch to less energetically efficient aerobic glycolysis. Due to difficulties in a...

2020-08-20 | MTBLS1390 | MetaboLights
MetabolomicsMulti-omics Analysis Reveals New Insights into Yak Lung Fibrosis Mechanisms Under High-Altitude Adaptation

The lung of yak is an important adaptive organ in the cold and low oxygen environment. Hypoxia can induce the pathological manifestations of pulmonary fibrosis in yak, but there was no study on hypoxia induced pulmonary fibrosis in yak. In this study full target metabolomics were used to conduct ...

2025-07-07 | MTBLS11648 | MetaboLights
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