Sort   by:  
 Page size 
UnknownHigh-dose pharmaceutical-grade biotin in patients with demyelinating neuropathies: a phase 2b open label, uncontrolled, pilot study.
Not available
S-EPMC10614347 | biostudies-literature
TranscriptomicsEffect of the explosive compound TNT on wild type seedlings
The aim of this experiment was to identify the genes involved in the detoxification of the toxic pollutant and explosive compound 2,4,6-trinitrotoluene (TNT). Fourteen-day-old, liquid culture grown, Arabidopsis seedlings, ecotype Col0 (NASC stock code N1093), were dosed with 60 uM TNT dissolved in 6...
ORGANISM(S): Arabidopsis thaliana 
2009-11-17 | E-GEOD-18983 | biostudies-arrayexpress
TranscriptomicsThe small molecule compound P2 in HCT116p53-/- and HCT116p53+/+ cells
Global gene expression in HCT116p53-/- and HCT116p53+/+ cells HCT116p53-/- and p53+/+ were untreated and treated with P2 small molecule compound at 25 microM, total RNA was isolated and gene expression was analyzed using Illumina chips
ORGANISM(S): Homo sapiens 
2012-11-23 | E-GEOD-33918 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse myoblast samples treated with a panel of compounds known to affect cellular differentiation or its reversal
A Single Cell Analysis of Myogenic Dedifferentiation Induced by Small Molecules An important direction in chemical biology is the derivation of compounds that affect cellular differentiation or its reversal. The fragmentation of multinucleate myofibers into viable mononucleates (called cellularisa...
ORGANISM(S): Mus musculus 
2005-08-20 | E-MEXP-401 | biostudies-arrayexpress
TranscriptomicsCompound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling.
Inhibiting the unfolded protein response (UPR) can be a therapeutic approach, especially for targeting the tumor microenvironment. We found that compound C (also known as dorsomorphin) prevented the UPR and exerted enhanced cytotoxicity during glucose deprivation. The UPR-inhibiting activity of comp...
ORGANISM(S): Homo sapiens 
2012-10-11 | E-GEOD-32911 | biostudies-arrayexpress
TranscriptomicsComparison of pan-inhibitor of HDACS (TSA) to specific HDAC8 inhibitor (HDAC Inhibitor XIX, Compound 2) in human myometrium
To compare gene expression in human myometrium after TSA treatment to gene expression after treatment with a specific HDAC8 inhibitor Four Control, four TSA and four Compound 2 samples (2 patients, replicated) derived from non-pregnant myometrial strips
ORGANISM(S): Homo sapiens 
2012-02-07 | E-GEOD-27124 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of yeast heterozygous diploid deletions strains screened with 20 compounds to identify gene deletions that confer sensitivity to each compound
The complete pool of barcoded essential heterozygous diploid deletion strains of S. cerevisiae were screened with 20 compounds from the Chembridge NOVACore chemical library to identify gene deletions that confer sensitivity to each compound.
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-13 | E-TABM-977 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast homozygous and essential heterozygous diploid deletion strains screened with 3-nitroso-imidazo[1,2-a]pyridines and -pyrimidines to identify gene deletions that confer sensitivity to each compound
The complete pool of barcoded homozygous and essential heterozygous diploid deletion strains of S. cerevisiae were screened with 3-nitroso-imidazo[1,2-a]pyridines and -pyrimidines to identify gene deletions that confer sensitivity to each compound.
ORGANISM(S): Saccharomyces cerevisiae 
2008-09-19 | E-TABM-560 | biostudies-arrayexpress
TranscriptomicsTracking distinct RNA populations using efficient and reversible covalent chemistry
We describe a chemical method to label and purify 4-thiouridine (s4U) -containing RNA. We demonstrate that methanethiolsulfonate (MTS) reagents form disulfide bonds with s4U more efficiently than the commonly used HPDP-biotin, leading to higher yields and less biased enrichment. This increase in eff...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-60988 | biostudies-arrayexpress
TranscriptomicsHigh-throughput expression profiling of OCI-Ly3 cell line upon treatment with a panel of 14 known drugs.
Analysis of Diffuse Large B-Cell Lymphoma (DLBCL) OCI-LY3 cell line treated with 14 different known drugs at 2 different concentrations and profiled at 6, 12 and 24 hrs after treatment. We used this gene expression data to design a challenge where participants were required to develop methods to pre...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-51068 | biostudies-arrayexpress
Sort   by:  
 Page size