Transcription profiling of mouse myoblast samples treated with a panel of compounds known to affect cellular differentiation or its reversal

ABSTRACT: A Single Cell Analysis of Myogenic Dedifferentiation Induced by Small Molecules An important direction in chemical biology is the derivation of compounds that affect cellular differentiation or its reversal. The fragmentation of multinucleate myofibers into viable mononucleates (called cellularisation) occurs during limb regeneration in urodele amphibians and the isolation of myoseverin, a tri-substituted purine that could apparently activate this pathway of myogenic dedifferentiation in mammalian cells, generated considerable interest. We have explored the mechanism and outcome of cellularisation at a single cell level, and report findings that significantly extend the previous work with myoseverin. Using a panel of compounds, including a novel triazine compound called 109 with struct

ORGANISM(S): Mus musculus

SUBMITTER: Anoop Kumar 

PROVIDER: E-MEXP-401 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress