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MetabolomicsMicroglia contributes to bipolar depression through Serinc2-dependent phospholipid synthesis

Although clinical research has revealed microglia-related inflammatory and immune responses in bipolar disorder (BD) patient brains, it remains unclear how microglia contribute to the pathogenesis of BD. Here, we demonstrated that Serinc2 is associated with susceptibility to BD and showed a reduc...

2025-08-27 | MTBLS12830 | MetaboLights
TranscriptomicsTranscriptome profiling of the human dorsal striatum in bipolar disorder
Bipolar disorder (BD) is a highly heritable and heterogeneous mental illness whose manifestations often include impulsive and risk-taking behavior. This particular phenotype suggests that abnormal striatal function could be involved in BD etiology, yet most transcriptomic studies of this disorder ha...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-80336 | biostudies-arrayexpress
TranscriptomicsHyper-excitability of Neurons generated from Patients with Bipolar Disorder
Bipolar Disorder (BD) is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression and, without treatment, 15% of patients commit suicide1. Hence, among all diseases, BD has been ranked by the WHO as a top disorder of morbidity and lost productivity2....
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-58933 | biostudies-arrayexpress
ProteomicsDysregulation of the complement and coagulation cascade in treated schizophrenia and bipolar disorder patients
A better understanding of the proteomic profile after bipolar disorder (BD) and schizophrenia (SCZ) treatment, through monitoring its progression, may assist the development of novel therapeutic strategies with the ability to reduce or control possible side effects. In this study, proteomics analysi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-11-07 | MSV000086425 | MassIVE
TranscriptomicsRNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms, and GTPase binding in bipolar disorder
See "Akula et al., Molecular Psychiatry in Press". RNA-sequencing (RNA-seq) is a powerful technique to investigate the complexity of gene expression in the human brain. We used RNA-seq to survey the brain transcriptome in high-quality post-mortem dorsolateral prefrontal cortex from 11 indi...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-53239 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of monocytes of bipolar patients and controls
Bipolar disorder (BD) is a psychiatric disorder in which the core feature is pathological disturbance in mood ranging from extreme elation (mania) to severe depression. Study has shown an aberrant pro-inflammatory status of monocytes/macrophages in mood disorders. Therefore, this study aimed at stud...
ORGANISM(S): Homo sapiens 
2008-01-01 | E-MEXP-1275 | biostudies-arrayexpress
TranscriptomicsState- and trait-specific gene expression in euthymia and mania
Gene expression profiles of bipolar disorder (BD) patients were assessed during both a manic and a euthymic phase and compared both intra-individually, and with the gene expression profiles of controls. 11 BD patients were assessed in their manic as well as in their euthymic phase. Comparison of gen...
ORGANISM(S): Homo sapiens 
2014-09-04 | E-GEOD-46416 | biostudies-arrayexpress
TranscriptomicsRNA expression in immortalized lymphocytes of schizophrenia and bipolar disorders patients and their unaffected relatives.
RNA expression in immortalized lymphocytes of schizophrenia and bipolar disorders patients were compared to that of their non-affected relatives to identify genes showing significant differences in expression. The study subjects were recruited in the Eastern Quebec kindred study.
ORGANISM(S): Homo sapiens 
2019-12-19 | E-MTAB-8018 | biostudies-arrayexpress
ProteomicsThe difference in serum proteomes in schizophrenia and bipolar disorder
Purpose of study is revealing significant differences in serum proteomes in schizophrenia, bipolar disorder (BD), and matched healthy controls. The sample preparation included affinity removing of six major proteins, separation by 1D electrophoresis, in-gel tryptic hydrolysis, and LC-MS/MS peptide a...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD009219 | Pride
One- dimensional gel electrophoresis Schizophrenia Proteomics Mass spectrometry Serum Biomarker Proteome Bipolar disorder 
TranscriptomicsGene expression from human prefrontal cortex (BA46)
Accumulating evidence suggests that mitochondrial dysfunction underlies the pathophysiology of bipolar disorder (BD) and schizophrenia (SZ). We performed large-scale DNA microarray analysis of postmortem brains of patients with BD or SZ, and examined expression patterns of mitochondria-related genes...
ORGANISM(S): Homo sapiens 
2008-09-03 | E-GEOD-12649 | biostudies-arrayexpress
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