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Transcriptomicsc-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice
The HGF/c-Met system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been demonstrated in acute liver regeneration its cell specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determ...
ORGANISM(S): Mus musculus 
2009-02-18 | E-GEOD-13992 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis of Schwann cells upon Wnt loss-of-function and gain-of-function treatments
Analysis of genes regulated by canonical Wnt signaling in the murine primary Schwann cells. Total RNA from b-catenin fl/fl Schwann cells, after introducing loss-of-function mutations with HTN-cre, or mimicking gain-of-function mutations with Chir98014 or Wnt3a-treatments, was compared to the respect...
ORGANISM(S): mus musculus 
2013-10-25 | E-MTAB-1943 | biostudies-arrayexpress
TranscriptomicsNotch signaling/MyoD double deficient embryonic muscle progenitors
Skeletal muscle growth and regeneration rely on myogenic progenitor and satellite cells, the stem cells of postnatal muscle. Elimination of Notch signals during mouse development results in premature differentiation of myogenic progenitors and formation of very small muscle groups. Here we show that...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-39379 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of E17.5 pituitary gland gene expression of control and Insm1 mutant mice
The Insm1 gene encodes a zinc finger factor expressed in many endocrine organs. We show here that Insm1 is required for differentiation of all endocrine cell types in the pituitary. Thus, in Insm1 mutant mice, hormones characteristic of the different pituitary cell types (thyroid, follicle and melan...
ORGANISM(S): Mus musculus 
2013-10-20 | E-GEOD-46139 | biostudies-arrayexpress
UnknownNeuregulin 3 promotes excitatory synapse formation on hippocampal interneurons
Not available
S-SCDT-EMBOJ-2017-98858 | biostudies-other
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