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TranscriptomicsExpression analysis of genes regulated by RBPJ (Notch) and Axin2 (Wnt) mediated signaling in mouse cardiogenesis at E9.25
Progenitor cells of the first and second heart fields (FHF and SHF) depend on cardiac-specific transcription factors for their differentiation. In mouse mutant embryos, we define the hierarchy of signaling events that controls the expression of cardiac-specific transcription factors during commitmen...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-36804 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis of Schwann cells upon Wnt loss-of-function and gain-of-function treatments
Analysis of genes regulated by canonical Wnt signaling in the murine primary Schwann cells. Total RNA from b-catenin fl/fl Schwann cells, after introducing loss-of-function mutations with HTN-cre, or mimicking gain-of-function mutations with Chir98014 or Wnt3a-treatments, was compared to the respect...
ORGANISM(S): mus musculus 
2013-10-25 | E-MTAB-1943 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of small intestinal gene expression of control and villinCre:Shp2fl mutant mice
Analysis of genes regulated by Shp2 mediated signaling in the small intestine Total RNA from small intestine of 6 villinCre;Shp2fl conditional mutant mice was compared to 6 control mice
ORGANISM(S): Mus musculus 
2014-02-24 | E-GEOD-50785 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mammospheres derived from tumors of mice harboring Wnt/Met signaling mutations treated Wnt and MET pathway inhibitors
The combined activation of Wnt/ß-catenin and MET/HGF is required for mammary cancer stem cell (MaCSC) maintenance. We generated mammospheres derived from tumors of mice harboring Wnt/Met signaling mutations on which we performed microarray analysis to evaluate gene expression signatures controlled b...
ORGANISM(S): Mus musculus 
2014-02-18 | E-GEOD-35899 | biostudies-arrayexpress
TranscriptomicsShp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430_2 array]
In this study, we have used techniques from cell biology, biochemistry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activation o...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-50517 | biostudies-arrayexpress
TranscriptomicsShp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array]
In this study, we have used techniques from cell biology, biochemistry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activation o...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-50516 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of colon cancer cell SW480_Control, _BOP1, _CKS2 and _NFIL3 treated with different inhibitors
SW480 cells overexpressing BOP1, CKS2 or NFIL3 migrated more actively compared to Control cells. Migration induced by BOP1, CKS2 or NFIL3 was repressed by interfering with distinct signaling systems using small- molecular-weight inhibitors, i.e., interference with PI3K, JNK and Notch in the case of ...
ORGANISM(S): Homo sapiens 
2015-08-04 | E-GEOD-50841 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of dorsal skin gene expression of control and K14-cre:Gab1fl mutant mice
Analysis of genes regulated by Gab1 mediated signaling in hair cycle initiation Total RNA from dorsal skin of control mice was compared to K14-cre; Gab1fl conditional mutant mice
ORGANISM(S): Mus musculus 
2015-02-08 | E-GEOD-35778 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of dorsal skin gene expression of control, Krox20-cre:Shp2fl, Krox20-cre; Mek1fstop/+ and double mutant mice
Analysis of genes regulated by Shp2 mediated signaling in hair cycle initiation which are rescued by overactivation of Mek1 Total RNA from dorsal skin of control mice was compared to transgenic mice
ORGANISM(S): Mus musculus 
2015-02-08 | E-GEOD-35779 | biostudies-arrayexpress
TranscriptomicsRNAseq transcriptomic signature associated depletion of Evi/Wls in epidermal sheets of mice, expression analysis of epidermal sheets of Evi/Wls knockout and wildtype mice
Evi/Wls is an essential Wnt secretion factor and important for tissue homeostasis. In the skin Wnt signaling plays an important role in hair follicle formation and maintenance. The aim of the present study is to compare the gene expression profile of Evi/Wls knockout epidermal sheets with wild-type ...
ORGANISM(S): Mus musculus 
2013-07-24 | E-MTAB-1613 | biostudies-arrayexpress
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