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TranscriptomicsFibrotic Myofibroblasts Manifest Genome-Wide Derangements of Translational Control
As a group, fibroproliferative disorders of the lung, liver, kidney, heart, vasculature and integument are common, progressive and refractory to therapy. They can emerge following toxic insults, but are frequently idiopathic. Their enigmatic propensity to resist therapy and progress to organ failure...
ORGANISM(S): Homo sapiens 
2008-11-20 | E-GEOD-11196 | biostudies-arrayexpress
TranscriptomicsAn extracellular matrix-driven positive feedback loop regulates translation in Idiopathic Pulmonary Fibrosis
Analysis of gene expression of lung fibroblasts seeded onto decellularized extracellular matrix (ECM). Experiment had 2x2 design where fibroblasts from idiopathic pulmonary fibrosis (IPF) or control patients were seeded onto decelluarized lung tissue from IPF or control patients allowing for determi...
ORGANISM(S): Homo sapiens 
2014-03-04 | E-GEOD-45686 | biostudies-arrayexpress
TranscriptomicseIF4E hypersensitive mRNA translation is characterized by long and structured untranslated regions
Combining a genetic and pharmacological approach, we modulated eIF4E activity across its physiological activity range and identified subsets of genes whose translation was either hypo- or hyper- sensitive to eIF4E activity changes. eIF4E hypersensitive genes had longer 5'UTRs with higher GC content;...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-56072 | biostudies-arrayexpress
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