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TranscriptomicsGenome wide analysis of bivalent domains in two HUES cell lines
Human embryonic stem (HUES) cells are derived from early individual embryos with unique genetic properties. However, how their epigenetic status might affect their potential to differentiate toward specific lineages remains a puzzling question. Using ChIP-on-chip, the status of bivalent domains on...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-59328 | biostudies-arrayexpress
GenomicsBivalent Chromatin Marks Developmental Regulatory Genes in the Mouse Embryonic Germline in Vivo
We developed a ChIP protocol for the analysis of histone marks using less than 10,000 cells per IP, and used it to investigate the chromatin state of E11.5 mouse primordial germ cells (PGCs). A genome-wide ChIP-Seq analysis of E11.5 PGCs revealed a distribution of H3K4me3/H3K27me3 bivalent domains h...
ORGANISM(S): Mus musculus 
2013-05-30 | E-GEOD-46396 | biostudies-arrayexpress
GenomicsMETTL14 Regulates Chromatin Bivalent Domains in Mouse Embryonic Stem Cells [RNA-seq]
METTL14 Regulates Chromatin Bivalent Domains in Mouse Embryonic Stem Cells [RNA-seq]
PRJNA851838 | ENA
GenomicsMETTL14 Regulates Chromatin Bivalent Domains in Mouse Embryonic Stem Cells [ChIP-seq]
METTL14 Regulates Chromatin Bivalent Domains in Mouse Embryonic Stem Cells [ChIP-seq]
PRJNA851833 | ENA
TranscriptomicsSCML2 establishes germline-specific bivalent domains.
Bivalent domains marked with repressive H3K27me3 and activating H3K4me2/3 are a molecular signature of totipotency in stem cells and development. While bivalent domains are retained throughout the germline to recover totipotency in the next generation, the mechanisms establishing bivalent domains re...
ORGANISM(S): Mus musculus 
2018-04-12 | GSE89502 | GEO
ProteomicsAncient origin and dynamic evolution of bivalent spider toxins
Bivalent peptide toxins comprising two cysteine-rich domains have evolved from single-domain precursors on multiple occasions in animal venoms, resulting in enhanced molecular target selectivity and avidity. Although bivalent toxins are emerging as prevalent in animal venoms, the genomic and evoluti...
ORGANISM(S): Lasiodora parahybana Fufius Hadronyche cerberea Chaetopelma olivaceum Cyrtocarenum grajum Brachypelma boehmei Avicularia avicularia Chilobrachys Harpactira 
2026-06-08 | PXD070138 | Pride
Australian funnel-web spider Inhibitor cystine knot Pi-hexatoxin Hi1a Spider venom Bivalent peptides Mygalomorphae 
GenomicsMapping polycomb complexes in human and mouse embryonic stem cells
In embryonic stem (ES) cells, bivalent chromatin domains with overlapping repressive (H3 lysine 27 tri-methylation) and activating (H3 lysine 4 tri-methylation) histone modifications mark the promoters of more than 2000 genes. To gain insight into the structure and function of bivalent domains, we m...
ORGANISM(S): Mus musculus 
2008-11-01 | E-GEOD-13084 | biostudies-arrayexpress
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20242 | biostudies-arrayexpress
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20236 | biostudies-arrayexpress
TranscriptomicsUnique cell cycle-dependent variations in the pluripotent epigenetic landscape define novel cohorts of temporal expressed bivalent genes during hESCs differentiation
By mapping the genomic enrichments  of H3K4me3 and H3K27me3 modifications in pure populations of hESCs during the G2, mitotic and G1 phases of the cell cycle, we characterize cell cycle-dependent variations in the epigenetic landscape of bivalent genes, altering the current view of mitotic inherita...
ORGANISM(S): Homo sapiens 
2015-12-23 | E-GEOD-55502 | biostudies-arrayexpress
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