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TranscriptomicsComparison of KrasG12D/WT;p53Fx/Fx and KrasG12D/G12D;p53Fx/Fx MEFs
Microarray expression data generated to compare the biological impact of KrasG12D allelic duplication in p53null mouse embryonic fibroblasts (MEFs). The RAS/MAPK-signalling pathway is frequently deregulated in non-small cell lung cancer (NSCLC), often through activating mutations in KRAS. Mouse mode...
ORGANISM(S): Mus musculus 
2016-02-24 | E-GEOD-75871 | biostudies-arrayexpress
UnknownMeta-Transcriptomic Analysis Uncovers the Presence of Four Novel Viruses and Multiple Known Virus Genera in a Single <i>Hibiscus rosa-sinensis</i> Plant in Colombia.
Not available
S-EPMC10891833 | biostudies-literature
TranscriptomicsA Genetic-to-Epigenetic Crosstalk Plays a Pivotal Role in the Promotion of KrasG12D-Induced Senescence and PanIN formation
Nupr1 is a chromatin protein which cooperates with KrasG12D to induce PanIN formation in mice, though the molecular mechanisms underlying this effect remain to be fully characterized. In the current study, we find that Nupr1 acts as a gene modifier of the effect of KrasG12D-induced senescence by reg...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-45232 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of control chimeric mouse embryos at embryonic days 7.5 and 8.5 of mouse development
Chimeric mouse embryos were generated as a control experiment to understand the contribution of host vs. injected cells to the developing embryo. Embryos were generated by blastocyst injection of tdTomato-labelled mouse embryonic stem cells into wild type embryos. After blastocyst harvest, cells wer...
ORGANISM(S): Mus musculus 
2018-12-05 | E-MTAB-7324 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of Tal1 knockout chimeric mouse embryos at embryonic day 8.5 of mouse development
Chimeric embryos were generated to investigate the effect of Tal1 knockout in mouse embryos by single-cell RNA-sequencing. Tal1 is an essential transcription factor for the formation of the embryonic blood. Embryo chimerism permits the analysis of the effects of Tal1 knockout without the confounding...
ORGANISM(S): Mus musculus 
2018-12-05 | E-MTAB-7325 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mammary glands from wild type and Akt1 knock out lactating mice at day 9 after parturition
A comparison of gene expression in the mammary gland of lactating mice at day 9 after parturition between Akt -/- and wildtype individuals.
ORGANISM(S): Mus musculus 
2006-12-31 | E-MEXP-891 | biostudies-arrayexpress
TranscriptomicsPre-B cell leukemia homeobox protein Pbx1 is associated with lupus susceptibility in mice and humans
Sle1a.1 is part of the Sle1a lupus susceptibility locus which results in the production of activated and autoreactive CD4+ T cells as well as a reduction in the peripheral regulatory T cell (Treg) pool. Sle1a.1 CD4+ T cells showed a defective response to retinoic acid (RA) expansion of TGFβ-induce...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-22313 | biostudies-arrayexpress
TranscriptomicsItaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation mechanism accompanying inflammatory macrophage activation. During this process, endogenous metabolites can adopt regulatory roles that govern specific aspects of inflammatory response, as recently shown for succinate, which r...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-82043 | biostudies-arrayexpress
UnknownQuantitative computed tomography of the lungs and airways in healthy nonsmoking adults.
Not available
S-EPMC3703944 | biostudies-literature
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