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GenomicsDNA methylation in mammalian placentas
Over the last 20-80 million years the mammalian placenta has taken on a variety of morphologies through both divergent and convergent evolution. Recently we have shown that the human placenta genome has a unique epigenetic pattern of large partially methylated domains (PMDs) and highly methylation ...
ORGANISM(S): Monodelphis domestica 
2015-08-05 | E-GEOD-63330 | biostudies-arrayexpress
TranscriptomicsMADS: a New and Improved Method for Analysis of Differential Alternative Splicing by Exon-tiling Microarrays
We describe a method, MADS (Microarray Analysis of Differential Splicing), for discovery of differential alternative splicing from exon tiling microarrays. MADS incorporates a series of low-level analysis algorithms motivated by the “probe-rich” design of exon arrays, including background correction...
ORGANISM(S): Mus musculus 
2008-05-09 | E-GEOD-11344 | biostudies-arrayexpress
TranscriptomicsPTB CLIP-seq
Recent transcriptome analysis indicates that >90% of human genes undergoes alternative splicing, underscoring the contribution of differential RNA processing to diverse proteomes in higher eukaryotic cells. The polypyrimidine tract binding protein PTB is a well-characterized splicing repressor, but ...
ORGANISM(S): Homo sapiens 
2009-12-24 | E-GEOD-19323 | biostudies-arrayexpress
TranscriptomicsGene expression based profiling of brains from mice infected with lethal Listeria monocytogenes over a 4-day period
Data presented here show that gene expression in the mouse brain changes during systemic infection relative to a steady state (uninfected control) mouse during systemic Listeria monocytogenes infection. Microarray analysis of gene expression in the brain following i.v. inoculation of 1-2 LD 50 L. ...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-10416 | biostudies-arrayexpress
UnknownEfficacy of a Chronic Care-Based Intervention on Secondary Stroke Prevention Among Vulnerable Stroke Survivors: A Randomized Controlled Trial.
Not available
S-EPMC5769158 | biostudies-literature
TranscriptomicsNetwork analysis of wood properties, gene expression levels and genotypes of natural Populus trichocarpa accessions
High-throughput approaches have been widely applied to elucidate the genetic underpinnings of industrially important wood properties. Each single wood trait was found to be highly polygenic in its nature. However, gene hierarchies need to be assessed with the most important gene variants controlling...
ORGANISM(S): Populus trichocarpa 
2013-02-26 | E-GEOD-44606 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of Gene expression in limb muscles of three mouse models of Kennedy disease/SBMA
Emerging evidence implicates transcriptional dyseregulation within skeletal muscle in the pathogenesis of Kennedy disease/spinal bulbar muscular atrophy (KD/SBMA). We therefore broadly characterized gene expression in skeletal muscle of three independently generated mouse models of this disorder. Th...
ORGANISM(S): Mus musculus 
2010-10-12 | E-GEOD-10190 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cerebral cortex using two model strains (C57BL/6 and ApoE(-/-) on the C57BL background) upon episode hypoxia treatment
Study the gene expression variation at cerebral cortex using two mouse model strains (C57BL/6 and ApoE(-/-) on the C57BL background) upon episode hypoxia treatment
ORGANISM(S): Mus musculus 
2013-01-30 | E-TIGR-135 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of adult male whole MutaMouse lung with its immortalized 100% confluent epithelial lung cell line counterpart UHN 15K Array
Biological comparison of gene expression profiles of a whole mouse lung from a transgenic mouse line with its immortalized cell line counterpart.
ORGANISM(S): Mus musculus 
2004-07-01 | E-MEXP-107 | biostudies-arrayexpress
TranscriptomicsTranscription profiling validation of an custom mouse oligo array using liver samples following treatment with the hepatotoxin phenobarbital and variable hybridization protocols
The use of custom-made focused microarrays has become a popular alternative, allowing the study of genes relevant to a specific hypothesis. To address the limitations of commercial arrays in toxicogenomics investigations, we have developed a custom mouse oligonucleotide microarray, the HC ToxArrayTM...
ORGANISM(S): Mus musculus 
2006-10-30 | E-MEXP-525 | biostudies-arrayexpress
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