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TranscriptomicsTranscriptome Microarray Gene Expression Analysis of Heliconius butterfly forewing and hindwing tissues across pupal development reveals genes underlying wing pattern variation
Heliconius butterfly wing pattern diversity offers a unique opportunity to investigate how natural genetic variation can drive the evolution of complex adaptive phenotypes. Here we took a large-scale transcriptomic approach to identify the network of genes involved in Heliconius wing pattern develop...
ORGANISM(S): Heliconius erato etylus x Heliconius himera 
2012-06-30 | E-GEOD-38084 | biostudies-arrayexpress
TranscriptomicsComparison of KrasG12D/WT;p53Fx/Fx and KrasG12D/G12D;p53Fx/Fx MEFs
Microarray expression data generated to compare the biological impact of KrasG12D allelic duplication in p53null mouse embryonic fibroblasts (MEFs). The RAS/MAPK-signalling pathway is frequently deregulated in non-small cell lung cancer (NSCLC), often through activating mutations in KRAS. Mouse mode...
ORGANISM(S): Mus musculus 
2016-02-24 | E-GEOD-75871 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of developing pea cotyledons over-expressing VfAAP1
Nitrogen application to legume seeds regulates seed metabolism and composition. In order to improve nitrogen flux into the embryo, the Vicia faba amino acid permease VfAAP1 (Miranda et al. Amino acid permeases in developing seeds of Vicia faba L.: expression precedes storage protein synthesis and is...
ORGANISM(S): Pisum sativum 
2008-05-01 | E-MEXP-1557 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Sinorhizobium meliloti wild type and Hfq ORF deletion strains
Hfq-dependent transcriptional alterations in the nitrogen-fixing endosymbiont S. meliloti. Comparison: S. meliloti 1021 strain Vs S. meliloti 1021Dhfq (containing a deletion of the hfq ORF).
ORGANISM(S): Sinorhizobium meliloti 
2010-12-01 | E-MEXP-2501 | biostudies-arrayexpress
TranscriptomicsItaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation mechanism accompanying inflammatory macrophage activation. During this process, endogenous metabolites can adopt regulatory roles that govern specific aspects of inflammatory response, as recently shown for succinate, which r...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-82043 | biostudies-arrayexpress
ProteomicsIdentification of proteins deregulated by platinum-based chemotherapy as novel biomarkers and therapeutic targets in non-small cell lung cancer
Platinum-based chemotherapy remains the cornerstone of treatment for most people with non-small cell lung cancer (NSCLC), either as adjuvant therapy in combination with a second cytotoxic agent or in combination with immunotherapy. Resistance to therapy, either in the form of primary refractory dise...
ORGANISM(S): Homo Sapiens 
PXD024209 | panorama
TranscriptomicsSinorhizobium meliloti 1021 delta divJ
Effect of deletion of DivJ kinase on the transcriptome of Sinorhizobium meliloti 1021.
ORGANISM(S): Sinorhizobium meliloti 
2013-07-29 | E-MEXP-3942 | biostudies-arrayexpress
GenomicsWTCCC2 Visceral Leishmaniasis (VL) samples
A WTCCC2 project genome-wide association study for visceral leishmaniasis (VL) in individuals from India, Brazil and Sudan, genotyped on the custom Illumina 670k array. The WTCCC2 analysis of the Brazilian and Indian samples is described in Fakiola et al. [Nat Genet. 2013 Feb;45(2):208-13]. It shoul...
EGAS00001000773 | EGA
TranscriptomicsThe role of IL33-ST2 in acute GVHD
Comparison between WT and ST2 knock-out T-cells upon allogenic stimulation in vitro for 48h
ORGANISM(S): Mus musculus 
2015-10-14 | E-MEXP-3954 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of Sinorhizobium meliloti in response to an osmotic upshift elicited by salt or sucrose
Time course of the S. meliloti response to an osmotic upshift elicited by salt (300mM or 400mM) or sucrose (500mM or 700mM)
ORGANISM(S): Sinorhizobium meliloti 
2006-08-17 | E-MEXP-785 | biostudies-arrayexpress
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