Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Sinorhizobium meliloti wild type and Hfq ORF deletion strains

ABSTRACT: Hfq-dependent transcriptional alterations in the nitrogen-fixing endosymbiont S. meliloti. Comparison: S. meliloti 1021 strain Vs S. meliloti 1021Dhfq (containing a deletion of the hfq ORF).

ORGANISM(S): Sinorhizobium meliloti

SUBMITTER: Jose Jimenez-Zurdo 

PROVIDER: E-MEXP-2501 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The Sinorhizobium meliloti RNA chaperone Hfq influences central carbon metabolism and the symbiotic interaction with alfalfa.

Torres-Quesada Omar O   Oruezabal Roke I RI   Peregrina Alexandra A   Jofré Edgardo E   Lloret Javier J   Rivilla Rafael R   Toro Nicolás N   Jiménez-Zurdo José I JI  

BMC microbiology 20100306

<h4>Background</h4>The bacterial Hfq protein is able to interact with diverse RNA molecules, including regulatory small non-coding RNAs (sRNAs), and thus it is recognized as a global post-transcriptional regulator of gene expression. Loss of Hfq has an extensive impact in bacterial physiology which in several animal pathogens influences virulence. Sinorhizobium meliloti is a model soil bacterium known for its ability to establish a beneficial nitrogen-fixing intracellular symbiosis with alfalfa.  ...[more]

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