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TranscriptomicsThe TAB1-p38α complex aggravates myocardial injury and can be targeted by small molecules
There is considerable evidence that inhibition of p38α mitogen-activated protein kinase diminishes cardiac damage during myocardial ischemia. During myocardial ischemia p38α interacts with TAB1, a scaffold protein, which promotes p38α autoactivation; active p38α (pp38α) then trans-phosphorylates TAB...
ORGANISM(S): Mus musculus 
2018-08-27 | E-MTAB-6460 | biostudies-arrayexpress
TranscriptomicsOvarian gene expression in the absence of FIGLA, an oocyte specific transcription factor
Ovarian folliculogenesis in mammals is a complex process involving cross talk between germ and somatic cells. Carefully orchestrated expression of transcription factors, cell adhesion molecules and growth factors are required for success. We have identified a germ-cell specific, basic helix-loop-hel...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-5802 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae response to nitrogen limitation in chemostat culture
Zinc is indispensable for the catalytic activity and structural stability of many proteins, and its deficiency can have severe consequences for microbial growth in natural and industrial environments. For example, Zn depletion in wort negatively affects beer fermentation and quality. Several studies...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-15 | E-GEOD-8089 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae to zinc limitation in chemostat cultures
Zinc is indispensable for the catalytic activity and structural stability of many proteins, and its deficiency can have severe consequences for microbial growth in natural and industrial environments. For example, Zn depletion in wort negatively affects beer fermentation and quality. Several studies...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-15 | E-GEOD-8035 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae reveals the regulation of reserve carbohydrate metabolism in S cerevisiae in response to nutrient availability
In Saccharomyces cerevisiae, glycogen and trehalose are important reserve carbohydrates that accumulate under nutrient limitation in batch cultures. An inherent draw-back of batch studies is that specific growth rate and substrate and product concentrations are variable over time and between culture...
ORGANISM(S): Saccharomyces cerevisiae 
2009-09-05 | E-GEOD-15465 | biostudies-arrayexpress
TranscriptomicsMolecular signatures of heterogeneous stem cell populations are resolved by linking single cell functional assays to single cell gene expression
The discovery of significant heterogeneity in the self-renewal durability of adult haematopoietic stem cells (HSCs) has challenged our understanding of the molecules involved in population maintenance throughout life. Gene expression studies in bulk populations are difficult to interpret since mult...
ORGANISM(S): Mus musculus 
2015-05-26 | E-GEOD-61533 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae response to carbon limitation in aerobic chemostat cultures
Zinc is indispensable for the catalytic activity and structural stability of many proteins, and its deficiency can have severe consequences for microbial growth in natural and industrial environments. For example, Zn depletion in wort negatively affects beer fermentation and quality. Several studies...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-15 | E-GEOD-8088 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of CD4+ T cells in experimental autoimmune encephalitomyelitis
In this study we determined whole genome gene expression of murine naive CD4+ T cells, in vitro differentiated Th17 cells, and CD4+ T cells isolated from experimental autoimmune encephalitomyelitis (EAE)-affected animals either after adoptive transfer of Th17 cells or after immunization with MOG35-5...
ORGANISM(S): Mus musculus 
2015-02-26 | E-GEOD-57098 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast to investigate the involvement of Snf7 and Rim101 in regulation of TIR1 and anaerobically up-regulated genes
Despite the scientific and applied interest in anaerobic metabolism of Saccharomyces cerevisiae, not all genes whose transcription is up-regulated under anaerobic conditions have yet been linked to known transcription factors. Experiments with a reporter construct in which the promoter of the anaero...
ORGANISM(S): Saccharomyces cerevisiae 
2009-10-02 | E-GEOD-18128 | biostudies-arrayexpress
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
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