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GenomicsDeletion of RING1A/B and loss of H2AK119ub1 affects PRC2 occupancy and H3K27me3 genome-wide
The chromatin modifying activities inherent to polycomb repressive complexes PRC1 and PRC2 play an essential role in gene regulation, cellular differentiation, and development. However, the mechanisms by which these complexes recognize their target sites and function together to form repressive chro...
ORGANISM(S): Mus musculus 
2014-05-27 | E-GEOD-55697 | biostudies-arrayexpress
TranscriptomicsDeletion of KDM2B DNA-binding domain affects RING1B and SUZ12 occupancy
The histone lysine demethylase protein, KDM2B, associates with the PCGF1/PRC1 complex and binds to non-methylated DNA through its ZF-CxxC domain, providing a possible molecular link between CpG island elements and polycomb nucleation (Farcas et al., 2012, Wu et al., 2013). Here, a novel genetic syst...
ORGANISM(S): Mus musculus 
2014-05-27 | E-GEOD-52619 | biostudies-arrayexpress
TranscriptomicsCpG islands recruit a histone H3 lysine 36 demethylase [Agilent data]
Transcription factors that bind small DNA motifs embedded in promoters play a central role in controlling gene expression. However, in addition to these elements, up to 70% of genes in higher eukaryotes also have high levels of non-methylated cytosine/guanine base pairs (CpGs) surrounding promoters ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-21201 | biostudies-arrayexpress
Genomicsproj022_chipseq
The mechanisms that recruit the major Polycomb-group (PcG) complexes PRC1 and PRC2 to target sites in vertebrate cells are not well understood. Building on recent studies that have determined a reciprocal relationship between DNA methylation and Polycomb activity, we demonstrate that in methylation ...
ORGANISM(S): Mus musculus 
2014-05-23 | E-MTAB-2481 | biostudies-arrayexpress
TranscriptomicsCapture-C experiments on auxin treated control (E14-Tir) and Scc1-AID, Ring1b-AID, Ring1b-AID-Scc1-AID and CTCF-AID (with and without a 6-hour auxin treatment) cells
The aim of the experiment was to gain a higher resolution for specific regions of interest to complement the Hi-C results. Capture-C experiments were performed on four-inducible degrons for Scc1, Ringb, Ring1b-Scc1 and CTCF, and Tir1 control, always in triplicates (three biological replicates per co...
ORGANISM(S): Mus musculus 
2020-01-23 | E-MTAB-7840 | biostudies-arrayexpress
UnknownHigher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC11872607 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
Not available
S-EPMC10957483 | biostudies-literature
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