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TranscriptomicsGenomic mapping of Six1 binding sites during skeletal myoblast differentiation
In this study, the C2C12 cell line, a model used to study myogenesis and regeneration, was allowed to differentiate from myoblast precursor cells to myotubes. Cells were harvested at 3 different timepoints to perform ChIP-on-Chip of Six1, which is a key muscle regulator. We identified global loci bo...
ORGANISM(S): Mus musculus 
2010-07-05 | E-GEOD-20150 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling of siRNA Knock-Down of Six1, Six4 and Myogenin in C2C12
Six1, Six4 and Myogenin are transcription factors that are known to be required for skeletal myogenesis. Currently, very little is known about the genes targeted by Six1 and Six4. Gene expression profiling when one or both transcription factors were knock-down by siRNA was performed to identify gene...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-19967 | biostudies-arrayexpress
GenomicsGenome-wide map of Six4 in C2C12 cells 24 hours post-differentiation
In this study, we used ChIP-seq to map Six4 binding profile in different C2C12 cell lines 24 hours after differentiation (T24). We performed ChIP-seq using two different antibodies: anti-Flag antibody in Flag-Six4 C2C12 cell line or in parental C2C12 cells; a custom-made anti-Six4 antibody in shNS ...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-66901 | biostudies-arrayexpress
TranscriptomicsGene expression profiling on C3H/10T1/2 fibroblasts during their myogenic conversion in case of Six4 ablation
In this study, we used C3H/10T1/2 cells, a well known model of myogenic conversion, to study the effect of Six4 knockdown on the expression of genes during fibroblasts to myocytes conversion induced by ectopic expression of MyoD We established C3H/10T1/2 cell line with stable Six4 knockdown by shor...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-66319 | biostudies-arrayexpress
TranscriptomicsExpression analysis of pre-phenotype dt27J mouse dorsal root ganglia
Loss of function of dystonin cytoskeletal linker proteins causes neurodegeneration in the sensory ataxia, dystonia musculorum (dt). While much investigation has focused on understanding dt pathology, divergent functions of dystonin isoforms are still unknown. Here, we highlight a novel function of...
ORGANISM(S): Mus musculus 
2012-02-23 | E-GEOD-30960 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T98G during asynchronous growth or under growth arrest by serum deprivation or contact inhibition
Triplicate experiments from T98G cells under asynchronously growing, and growth arrest by serum deprivation and contact inhibition.
ORGANISM(S): Homo sapiens 
2007-11-06 | E-GEOD-1692 | biostudies-arrayexpress
TranscriptomicsEffect of in utero undernutrition on skeletal muscle gene expression
In utero undernutrition is associated with obesity and insulin resistance, although its effect on skeletal muscle remains poorly defined. We report that, in mice, adult offspring from undernourished dams have decreased energy expenditure, decreased skeletal muscle mitochondrial content, and altered ...
ORGANISM(S): Mus musculus 
2014-08-01 | E-GEOD-53520 | biostudies-arrayexpress
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