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TranscriptomicsTranscriptional profiling of bulge stem cells
In adult skin, each hair follicle contains a reservoir of stem cells (the bulge), which can be mobilized to regenerate the new follicle with each hair cycle and to reepithelialize epidermis during wound repair. Here we report new methods that permit their clonal analyses and engraftment and demonstr...
ORGANISM(S): Mus musculus 
2012-10-19 | E-GEOD-41704 | biostudies-arrayexpress
ProteomicsFat1 deletion promotes hybrid EMT state, tumor stemness, and metastasis
FAT1, a protocadherin, is among the most frequently mutated genes in human cancers1-5. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. In the present study we used different mouse cancer models including skin squ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD022268 | Pride
Stemness Fat1 Hybrid emt Metastasis 
TranscriptomicsExpression data from sorted interfollicular basal cells (alpha6 integrin-high/CD34-neg) from K14CREER and InvCREER/RosaYFP induced mice
The skin interfollicular epidermis (IFE) is the first barrier against the external environment and its maintenance is critical for survival. Two seemingly opposite theories have been proposed to explain IFE homeostasis. One posits that IFE is maintained by a long-lived slow-cycling stem cell (SC) po...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36688 | biostudies-arrayexpress
TranscriptomicsExpression data from sorted epithelial CD34+ expressing cells from DMBA/TPA induced skin tumors
Transcriptional profile of control and VEGF overexpressing FACS-isolated CD34+ Cancer stem cells from DMBA/TPA induced skin tumours Tumours were digested in collagenase I (Sigma) for 2 hours at 37°C on a rocking plate. Collagenase I activity was blocked by addition of EDTA (5mM) and then rinced in ...
ORGANISM(S): Mus musculus 
2011-09-06 | E-GEOD-31465 | biostudies-arrayexpress
GenomicsGenomic landscape of carcinogen induced mouse skin squamous cell carcinoma: whole-exome sequencing
Whole-exome sequencing of induced murine squamous cell carcinoma. 26 samples are included.
ORGANISM(S): Mus musculus 
2014-09-11 | E-MTAB-2887 | biostudies-arrayexpress
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