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MetabolomicsdTor affects the fat body lipidome via Nep1r1, Ctdnep1 and Lipin
Not available
ORGANISM(S): Drosophila melanogaster 
ST001859 | MetabolomicsWorkbench
ProteomicsFat1 deletion promotes hybrid EMT state, tumor stemness, and metastasis
FAT1, a protocadherin, is among the most frequently mutated genes in human cancers1-5. However, the role and the molecular mechanisms by which FAT1 mutations control tumour initiation and progression are poorly understood. In the present study we used different mouse cancer models including skin squ...
ORGANISM(S): Homo sapiens (Human) 
2021-01-18 | PXD022268 | Pride
Stemness Fat1 Hybrid emt Metastasis 
MetabolomicsDendrobium officinale Polysaccharide Ameliorates High-Fat Diet-Induced Hepatic Lipid Metabolic Disorder via the SIRT6/PGC-1α Signaling Axis
Aims: This study aims to explore the potential therapeutic effect of Dendrobium officinale polysaccharide (DOP) on non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet (HFD), and to elucidate the underlying mechanism involving the SIRT6/PGC-1α signaling axis and the regulation of the g...
2026-05-25 | MTBLS14575 | MetaboLights
ProteomicsEndothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Activation of endothelial YAP/TAZ signaling is crucial for physiological and pathological angiogenesis. The mechanisms of endothelial YAP/TAZ regulation are, however, incompletely understood. Here we report that the protocadherin FAT1 acts as a critical upstream regulator of endothelial YAP/TAZ whic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-02-14 | MSV000091279 | MassIVE
TranscriptomicsFAT1 knockdown in immortalized astrocyte and glioma cell lines
The FAT1 gene was knocked down using 2 independent siRNAs, in immortalized human astrocytes and U87 and U251 glioma cell lines. A non-targeted scramble siRNA was used as a control. Scramble, FAT1 siRNA#1 and FAT1 siRNA#2 were transfected into each cell line, in duplicate, and RNA analyzed using the...
ORGANISM(S): Homo sapiens 
2013-01-10 | E-GEOD-40583 | biostudies-arrayexpress
ProteomicsFat1 is atarget antigen in de novo allograft membranous nephropoathy associated with antibody mediated rejection.
Membranous nephropathy (MN) occurs either as recurrent or de novo MN in the kidney allograft. Recurrent MN is most often associated with antibodies to the target antigen M-type phospholipase A2 receptor (PLA2R). 1-3 Most cases of de novo MN are PLA2R-negative and the target antigen in unknown.2 We h...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD055559 | Pride
Kidney transplant. Fat1 De novo membranous nephropathy 
GenomicsNovel Homozygous FAT1 Mutation Causes glomerulotubular nephropathy in Asian adult
Novel Homozygous FAT1 Mutation Causes glomerulotubular nephropathy in Asian adult
PRJNA1187624 | ENA
GenomicsTranscriptional response in ileum tissue from wild-type and Fat1+/- male mice
Transcriptional response in ileum tissue from wild-type and Fat1+/- male mice
PRJNA550521 | ENA
GenomicsFat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis (exome)
Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis (exome)
PRJNA665476 | ENA
GenomicsFat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis (human RNA-Seq)
Fat1 deletion promotes hybrid EMT state with enhanced tumor progression, stemness, and metastasis (human RNA-Seq)
PRJNA665475 | ENA
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