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MetabolomicsMetabolomic signatures in blastocyst spent culture medium as noninvasive predictors of live birth: a pilot study

Research Question: Can metabolomic profiling of blastocyst spent culture medium (SCM) serve as a non-invasive tool to predict live birth?

Design: This pilot study investigated the association between metabolite profiles in SCM and clinical outcomes following single blastocyst transfer. Seve...

2026-02-13 | MTBLS13898 | MetaboLights
TranscriptomicsThe absence of a Ca(2+) signal during mouse egg activation can affect development and gene expression patterns
The absence of a Ca(2+) signal during mouse egg activation can affect parthenogenetic preimplantation development, gene expression patterns, and blastocyst quality. Gene expression pattern of parthenogenetic mouse embryos by cycloheximide or Sr2+. Keywords: development or differentiation design Gene...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-5077 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the oocyte quality
Microarray analysis was performed in ooplast samples to identify gene expression profiles associated with the embryo capacity to develop to blastocyst stage A fraction of the cytoplasm from in vitro matured oocytes was collected and snap frozen. The oocytes were chemically activated and presumptive ...
ORGANISM(S): Bos taurus 
2013-12-27 | E-GEOD-29191 | biostudies-arrayexpress
GenomicsHuman blastoids model blastocyst development and implantation
Human blastoids model blastocyst development and implantation
PRJNA737139 | ENA
Proteomics,Multiomicsembryo_proteome
We collected over 8000 mouse embryos of each developmental stage (zygote, 2-cell, 4-cell, 8-cell, morula, blastocyst) and performed tandem mass tag (TMT)-based quantitative mass spectrometry and identified nearly 5000 proteins for each stage. In-depth analysis indicates that protein expression profi...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2015-12-10 | MSV000079417 | MassIVE
TranscriptomicsThe growth factor environment defines distinct pluripotent ground states in novel blastocyst derived stem cells
Pluripotent stem cell lines can be derived from blastocyst embryos, which yield embryonic stem cell lines (ES cells), as well as the post-implantation epiblast, which gives rise to epiblast stem cell lines (EpiSCs). Remarkably, ES cells and EpiSCs display profound differences in the combination of g...
ORGANISM(S): Mus musculus 
2010-05-17 | E-GEOD-12519 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of preimplantation mouse embryos to study the requirement of the MAP kinase signaling pathway for preimplantation development.
We examined expression profiles of genes that could be regulated by the MAPK pathways during mouse preimplantation development. We used Affymetrix GeneChips for microarray analysis, and three independent experiments were carried out. 8-cell stage embryos were treated or untreated with MAPK inhibit...
ORGANISM(S): Mus musculus 
2007-09-25 | E-GEOD-2229 | biostudies-arrayexpress
TranscriptomicsDiscovery of candidate genes and pathways in the endometrium regulating ovine blastocyst growth and conceptus elongation
Establishment of pregnancy in ruminants requires blastocyst growth to form an elongated conceptus that produces interferon tau, the pregnancy recognition signal, and initiates implantation. Blastocyst growth and development requires secretions from the uterine endometrium. An early increase in circu...
ORGANISM(S): Ovis aries 
2010-05-15 | E-GEOD-17401 | biostudies-arrayexpress
GenomicsHuman blastoids model blastocyst development and implantation [scRNAseq]
Human blastoids model blastocyst development and implantation [scRNAseq]
PRJNA737134 | ENA
GenomicsHuman blastoids model blastocyst development and implantation [Bulk RNA-seq]
Human blastoids model blastocyst development and implantation [Bulk RNA-seq]
PRJNA742004 | ENA
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