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GenomicsGene expression differences among primates are associated with changes in a histone epigenetic modification
Changes in gene regulation are thought to play an important role in speciation and adaptation, especially in primates. However, we still know relatively little about the mechanisms underlying regulatory evolution. In particular, the extent to which epigenetic modifications underlie gene expression d...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-24111 | biostudies-arrayexpress
TranscriptomicsGenome-wide inter-primate comparison of gene expression profiles in multiple tissues
Regulatory changes have long been hypothesized to play an important role in primate evolution. To identify adaptive regulatory changes in humans, we performed a genome-wide survey for genes whose regulation evolves under natural selection. To do so, we used a novel multi-species microarray to measur...
ORGANISM(S): Macaca mulatta 
2008-09-17 | E-GEOD-11560 | biostudies-arrayexpress
TranscriptomicsSex-specific and lineage-specific alternative splicing in primates
Comparative studies of gene regulation suggest an important role for natural selection in shaping gene expression patterns within and between species. Most of these studies, however, estimated gene expression levels using microarray probes designed to hybridize to only a small proportion of each gen...
ORGANISM(S): Homo sapiens 
2009-12-01 | E-GEOD-17274 | biostudies-arrayexpress
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
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