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TranscriptomicsOpposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
Polycomb group (PcG) proteins are transcriptional repressors with a central role in the establishment and maintenance of gene expression patterns during development. We have investigated the role of Polycomb Repressive Complexes (PRCs) in hematopoietic stem cells (HSCs) and progenitor populations. W...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21404 | biostudies-arrayexpress
TranscriptomicsJarid2 regulates hematopoietic stem cell function by acting with Polycomb Repressive Complex 2
Polycomb Repressive Complex 2 (PRC2) has been shown to play a key role in hematopoietic stem and progenitor cell (HSPC) function. Analyses of mouse mutants harboring deletions of core components have implicated PRC2 in fine-tuning multiple pathways that instruct HSPC behavior, yet how PRC2 is target...
ORGANISM(S): Mus musculus 
2015-04-02 | E-GEOD-60808 | biostudies-arrayexpress
GenomicsA comparison of control samples for ChIP-seq of histone modifications
The advent of high-throughput sequencing has allowed genome wide profiling of histone modifications by Chromatin ImmunoPrecipitation (ChIP) followed by sequencing (ChIP-seq). In this assay the histone mark of interest is enriched through a chromatin pull-down assay using an antibody for the mark. Du...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-59419 | biostudies-arrayexpress
Genomicsena-DATASET-BAMS-05-01-2017-02:07:22:122-13 - samples
Whole exome sequencing data for patients with Bosma arhinia microphthalmia syndrome (BAMS). The dataset includes 21 samples from 7 families with BAMS; see Gordon et al, Nature Genetics, 2017.
EGAD00001003130 | EGA
TranscriptomicsDNA methylation differences between human regulatory T cells and conventional T cells
Regulatory T cells (Treg) prevent the emergence of autoimmune disease. Prototypic natural Treg (nTreg) are programmed by Forkhead-box P3 (FOXP3) and can be reliably identified by demethylation at the FOXP3 locus. To explore the nTreg methylation landscape we performed genome-wide methylation studies...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-49667 | biostudies-arrayexpress
GenomicsWhole exome sequencing data for patients with Bosma arhinia microphthalmia syndrome (BAMS).
The datasets includes 21 samples from 7 families with Bosma arhinia microphthalmia (BAMS). For details of the study please refer to the manuscript "De novo mutations in SMCHD1 cause Bosma arhinia microphthalmia syndrome and abrogate nasal development", Nature Genetics 2017. Each sample was exome seq...
EGAS00001002193 | EGA
GenomicsData access committee for BAMS exome sequencing data.
Data Access Committee EGAC00001000583
EGAC00001000583 | EGA
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